PAPA NONOate

Modify Date: 2024-01-11 18:28:11

PAPA NONOate structure	Common Name	PAPA NONOate
	CAS Number	146672-58-4	Molecular Weight	176.217
	Density	1.2±0.1 g/cm3	Boiling Point	277.2±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	121.4±27.9 °C

Use of PAPA NONOate

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

Name	N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide
Synonym	More Synonyms

Description	PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
Related Catalog	Research Areas >> Endocrinology
In Vitro	PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].
In Vivo	PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group.

Density	1.2±0.1 g/cm3
Boiling Point	277.2±42.0 °C at 760 mmHg
Molecular Formula	C₆H₁₆N₄O₂
Molecular Weight	176.217
Flash Point	121.4±27.9 °C
Exact Mass	176.127319
PSA	82.16000
LogP	0.20
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.523
Storage condition	-20℃