PAPA NONOate
Modify Date: 2024-01-11 18:28:11
PAPA NONOate structure
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Common Name | PAPA NONOate | ||
|---|---|---|---|---|
| CAS Number | 146672-58-4 | Molecular Weight | 176.217 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 277.2±42.0 °C at 760 mmHg | |
| Molecular Formula | C6H16N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 121.4±27.9 °C | |
Use of PAPA NONOatePAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3]. |
| Name | N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide |
|---|---|
| Synonym | More Synonyms |
| Description | PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3]. |
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| Related Catalog | |
| In Vitro | PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1]. |
| In Vivo | PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 277.2±42.0 °C at 760 mmHg |
| Molecular Formula | C6H16N4O2 |
| Molecular Weight | 176.217 |
| Flash Point | 121.4±27.9 °C |
| Exact Mass | 176.127319 |
| PSA | 82.16000 |
| LogP | 0.20 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.523 |
| Storage condition | -20℃ |
| 3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine |
| 1-Propanamine, 3-(2-hydroxy-3-oxo-1-propyltriazanyl)- |
| 1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl-1-triazene |
| PAPA NONOate |
| 1-Propanamine,3-(2-hydroxy-2-nitroso-1-propylhydrazinyl) |
| 1-(3-Aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane |
| NOC-15 |