146672-58-4

146672-58-4 structure

Name: PAPA NONOate
Chemical Name: N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide
CAS Number: 146672-58-4
Molecular Formula: C₆H₁₆N₄O₂
Molecular Weight: 176.217
Catalog: Research Areas Endocrinology
Create Date: 2016-05-15 15:54:50
Modify Date: 2024-01-11 18:28:11
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

Name	N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide
Synonyms	3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine 1-Propanamine, 3-(2-hydroxy-3-oxo-1-propyltriazanyl)- 1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl-1-triazene PAPA NONOate 1-Propanamine,3-(2-hydroxy-2-nitroso-1-propylhydrazinyl) 1-(3-Aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane NOC-15

Description	PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
Related Catalog	Research Areas >> Endocrinology
In Vitro	PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].
In Vivo	PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group.

Hazard Codes	Xn
Risk Phrases	R22