Phytanic acid

Modify Date: 2024-01-05 12:16:58

Phytanic acid Structure
Phytanic acid structure
Common Name Phytanic acid
CAS Number 14721-66-5 Molecular Weight 312.530
Density 0.9±0.1 g/cm3 Boiling Point 422.3±13.0 °C at 760 mmHg
Molecular Formula C20H40O2 Melting Point -65°C
MSDS Chinese USA Flash Point 179.7±11.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Phytanic acid


Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease[1][2][3][4][5].

 Names

Name phytanic acid
Synonym More Synonyms

 Phytanic acid Biological Activity

Description Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease[1][2][3][4][5].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Budden SS, et al. Dysmorphic syndrome with phytanic acid oxidase deficiency, abnormal very long chain fatty acids, and pipecolic acidemia: studies in four children. J Pediatr. 1986 Jan;108(1):33-9.  

[3]. McLean BN, et al. A new defect of peroxisomal function involving pristanic acid: a case report. J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):396-9.  

[4]. Baumgartner MR, et al. Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol. 1998 Nov;44(5):720-30.  

[5]. Poll-The BT, et al. Infantile Refsum's disease: biochemical findings suggesting multiple peroxisomal dysfunction. J Inherit Metab Dis. 1986;9(2):169-74.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 422.3±13.0 °C at 760 mmHg
Melting Point -65°C
Molecular Formula C20H40O2
Molecular Weight 312.530
Flash Point 179.7±11.2 °C
Exact Mass 312.302826
PSA 37.30000
LogP 8.54
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.454
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2915900090

 Synthetic Route

~71%

Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Hirai, Kunihiro; Katayama, Satoshi; Torii, Takayoshi; Nakaya, Ryotaro; Takahashi, Daisuke Patent: US2013/267697 A1, 2013 ; Location in patent: Page/Page column ;

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Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Karrer; Epprecht; Koenig Helvetica Chimica Acta, vol. 23, p. 280

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Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Kvita,V.; Weichet,J. Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 254 - 257

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Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Kvita,V.; Weichet,J. Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 254 - 257

~%

Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Karrer; Epprecht; Koenig Helvetica Chimica Acta, vol. 23, p. 280

~%

Phytanic acid Structure

Phytanic acid

CAS#:14721-66-5

Literature: Willstaetter; Mayer; Hueni Justus Liebigs Annalen der Chemie, 1911 , vol. 378, p. 114

 Customs

HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

 Articles61

More Articles
Phytanic acid and very long chain fatty acids in genetic peroxisomal disorders.

J. Clin. Chem. Clin. Biochem. 27(5) , 309-14, (1989)

1. Phytanic acid, phytanyl-triacylglycerols, and very long chain fatty acids were analysed by gas chromatography or thin-layer chromatography in blood and tissues of patients with different genetic pe...

Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells.

PLoS ONE 10 , e0132761, (2015)

The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remain...

New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes.

Biochim. Biophys. Acta 1853(1) , 111-25, (2014)

Peroxisomes are ubiquitous organelles which participate in a variety of essential biochemical pathways. An intimate interrelationship between peroxisomes and mitochondria is emerging in mammals, where...

 Synonyms

3,7,11,15-Tetramethylhexadecanoic acid
(7R,11R)-3,7,11,15-Tetramethylhexadecanoic acid
Hexadecanoic acid, 3,7,11,15-tetramethyl-, (7R,11R)-
Phytanic acid