Nef-IN-B9
Modify Date: 2025-08-27 08:51:40
Nef-IN-B9 structure
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Common Name | Nef-IN-B9 | ||
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| CAS Number | 1473404-51-1 | Molecular Weight | 402.813 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H11ClN6O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nef-IN-B9Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM. |
| Name | Nef-IN-B9 |
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| Description | Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM. |
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| References | References 1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91. View Related Products by Target HIV |
| Molecular Formula | C16H11ClN6O3S |
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| Molecular Weight | 402.813 |
| InChIKey | LEQSBTDRMOZWRP-UHFFFAOYSA-N |
| SMILES | NC(=S)n1[nH]c(-c2ccc([N+](=O)[O-])cc2)c(N=Nc2cccc(Cl)c2)c1=O |