147403-52-9

147403-52-9 structure

Name: 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester
Chemical Name: methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
CAS Number: 147403-52-9
Molecular Formula: C₂₆H₂₂N₄O₅
Molecular Weight: 470.477
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2018-07-29 11:50:20
Modify Date: 2026-07-01 09:21:39
Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension[1].

Name	methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Synonyms	1-[(2'-[(Ethoxycbonyl)oxy]amidino)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-cboxylicacidmethylester Methyl 2-ethoxy-1-{[2'-(5-hydroxy-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate Azilsan medoxomil-2 AzilstanMedoxoMilInterMediates-2 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester ISO 9001：2015 REACH 1-[[2'-(2,5-DIHYDRO-5-OXO-1,2,4-OXADIAZOL-3-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-2-ETHOXY-1H-BENZIMIDAZOLE-7-CBOXYLIC 147-9 2-Ethoxy-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-cboxylic acid methyl ester Azilstan medoxomil impurity221 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester methyl 1-[[2'-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate BEN731 methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-cboxylate 1H-BenziMidazole-7-cboxylicacid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-,Methylester Azilstan Methyl ester methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) Azilstan phmaceutical intermediate-2 Azilstan Methyl Ester Impurity 1-Methyl-[2’-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-2-ethoxy-1-H-benzimidazole-7-cboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazol 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1h-benzimidazole-7-carboxylic acid methyl ester intermediates of Azilstan Medoximil 1H-Benzimidazole-7-Cboxylic Acid-1-[[2'-(2, 5-Dihydro-5-Oxo-1, 2, 4-Oxadiazol-3-yl)[1,1'-Biphenyl]-4-Yl]Methyl]-5-Oxo-1, 2, 4-Oxadiazol-3-yl)[1,1'-Biphenyl]-4-Yl]Methyl]-2-Ethoxy-, Methyl Ester 1-((2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1h-benzimidazole-7-cboxylic acid methyl ester methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 2-Ethoxy-1-｛[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]Methyl｝-1H-benzo -[d]iMidazole-7- cboxylic acid Methyl ester Azilstan Methyl Ester, 10 mM in DMSO (Z)-Methyl 2-ethoxy-3-((2'-(N'-(ethoxycbonyloxy)cbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-cboxylate Methyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-cboxylate 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-bipheny 1- [(2 '- [(ethoxycbonyl) oxy] amidinyl) [1,1-biphenyl] -4-yl) methyl] -2-ethoxy-1H-benzimidazol-7 formate methyl ester Methyl 1-[[2'-(2,5-Dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl] methyl] -2-ethoxy-1H-benzimidazole-7-cboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'- biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazol methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid methyl ester Azilstan impurity U Methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate Methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-1H-benzo[d]iMidazole-7-cboxylate Methyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid methyl ester (Azilstan Impurity) Azilstan Impurity 4 Azilstan Methyl Ester Azilstan Medoxomil Ester Impurity Azilstan Acid Methyl Ester Methyl 2-ethoxy-1-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-cboxylate me: 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester 1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-,methyl ester 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4 Azilstan impurity 24/Methyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate Azilstan medoxomil impurity1 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl) Azilastan Impurity-4

Description	Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
References	[1]. Alison Handley, et al. Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study. Clin Exp Hypertens. 2016;38(2):180-8.

Density	1.4±0.1 g/cm3
Boiling Point	652.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₂N₄O₅
Molecular Weight	470.477
Flash Point	348.1±34.3 °C
Exact Mass	470.159027
PSA	112.24000
LogP	4.51
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.665

Hazard Codes	Xi

Precursor 7
102-09-0 147403-65-4 32315-10-9 503-38-8
530-62-1 105-58-8 616-38-6
DownStream 2
863031-21-4 147403-03-0

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