doripenem
Modify Date: 2024-01-02 22:34:16
doripenem structure
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Common Name | doripenem | ||
|---|---|---|---|---|
| CAS Number | 148016-81-3 | Molecular Weight | 420.504 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 694.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C15H24N4O6S2 | Melting Point | >186ºC dec. | |
| MSDS | N/A | Flash Point | 374.0±34.3 °C | |
Use of doripenemDoripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.Target: AntibacterialDoripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism. |
| Name | Doripenem |
|---|---|
| Synonym | More Synonyms |
| Description | Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.Target: AntibacterialDoripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism. |
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| Related Catalog | |
| References |
[1]. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 694.8±65.0 °C at 760 mmHg |
| Melting Point | >186ºC dec. |
| Molecular Formula | C15H24N4O6S2 |
| Molecular Weight | 420.504 |
| Flash Point | 374.0±34.3 °C |
| Exact Mass | 420.113739 |
| PSA | 195.74000 |
| LogP | -3.65 |
| Vapour Pressure | 0.0±4.9 mmHg at 25°C |
| Index of Refraction | 1.681 |
| Storage condition | -20°C Freezer |
| Hazard Codes | N |
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CAS#:148017-07-6| doripenem |
| S 4661 |
| InterMediates of DoripeneM |
| (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]-3-pyrrolidinyl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)- |