多利培南

• 常用名: 多利培南
• 英文名: doripenem
• CAS号: 148016-81-3
• 分子量: 420.504
• 密度: 1.6±0.1 g/cm3
• 沸点: 694.8±65.0 °C at 760 mmHg
• 分子式: C₁₅H₂₄N₄O₆S₂
• 熔点: >186ºC dec.
• 闪点: 374.0±34.3 °C

多利培南用途

Doripenem是β-内酰胺广谱抗生素,对革兰氏阳性菌、阴性菌和厌氧菌均有效。

多利培南名称

• 中文名: 多尼培南
• 英文名: Doripenem
• 中文别名: 多立培南 | (+)-(4R,5S,6S)-6-[(1R)-1-羟基乙基]-4-甲基-7-氧代-3-[[(3S,5S)-5-[(氨基磺酰氨基)-甲基]-3-吡咯烷基]硫]-1-氮杂双环[3.2.0]庚-2-烯-2-甲酸 | 多利培南

多利培南生物活性

• 描述: Doripenem是β-内酰胺广谱抗生素,对革兰氏阳性菌、阴性菌和厌氧菌均有效。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404.

  [2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.

多利培南物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 694.8±65.0 °C at 760 mmHg
• 熔点: >186ºC dec.
• 分子式: C₁₅H₂₄N₄O₆S₂
• 分子量: 420.504
• 闪点: 374.0±34.3 °C
• 精确质量: 420.113739
• PSA: 195.74000
• LogP: -3.65
• InChIKey: AVAACINZEOAHHE-VFZPANTDSA-N
• SMILES: CC(O)C1C(=O)N2C(C(=O)O)=C(SC3CNC(CNS(N)(=O)=O)C3)C(C)C12
• 外观性状: 白色至灰白色粉末
• 蒸汽压: 0.0±4.9 mmHg at 25°C
• 折射率: 1.681
• 储存条件: -20°C Freezer

多利培南安全信息

• 危害码 (欧洲): N

多利培南靶点实验

查看更多实验

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实验名称：Antibacterial activity against Pseudomonas aeruginosa P352 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267707

实验名称：Antibacterial activity against Pseudomonas aeruginosa P353 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267708

实验名称：Antibacterial activity against Pseudomonas aeruginosa P365 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267709

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Antibacterial activity against Pseudomonas aeruginosa P340 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267710

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多利培南英文别名

• doripenem
• S 4661
• InterMediates of DoripeneM
• (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]-3-pyrrolidinyl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid