Chrysosplenol D

Modify Date: 2024-01-03 11:13:27

Chrysosplenol D structure	Common Name	Chrysosplenol D
	CAS Number	14965-20-9	Molecular Weight	360.315
	Density	1.5±0.1 g/cm3	Boiling Point	645.0±55.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₆O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	237.3±25.0 °C

Use of Chrysosplenol D

Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].

Name	2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
Synonym	More Synonyms

Description	Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1]. Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2]. Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2]. Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2]. Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3].
In Vivo	Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2]. Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4]. Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4].
References	[1]. Habib ES, et, al. Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. Nat Prod Res. 2020 Aug 4;1-5. [2]. Lang SJ, et, al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020 Jun 8;21(11):4090. [3]. Skaf J, et, al. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018 Mar;125:191-198. [4]. Li YJ, et, al. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8.

Density	1.5±0.1 g/cm3
Boiling Point	645.0±55.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₆O₈
Molecular Weight	360.315
Flash Point	237.3±25.0 °C
Exact Mass	360.084503
PSA	118.59000
LogP	2.29
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.680

Hazard Codes	Xi
HS Code	2914509090

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%