Sacubitril sodium
Modify Date: 2024-01-08 12:42:34
Sacubitril sodium structure
|
Common Name | Sacubitril sodium | ||
|---|---|---|---|---|
| CAS Number | 149690-05-1 | Molecular Weight | 433.47300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28NNaO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sacubitril sodiumSacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3]. |
| Name | sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Sacubitril sodium increases neprylisin-degraded peptides, such as natriuretic peptides (NPs), peptide natriuretic atrial (ANP) and peptide natriuretic brain (BNP)[2]. |
| In Vivo | In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)[1]. Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats[1]. |
| References |
| Molecular Formula | C24H28NNaO5 |
|---|---|
| Molecular Weight | 433.47300 |
| Exact Mass | 433.18700 |
| PSA | 99.02000 |
| LogP | 4.54780 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:149709-62-6| AHU-377 sodium salt |
| UNII-MOP72GEP8Z |