PD-85639
Modify Date: 2024-02-05 14:21:55
PD-85639 structure
|
Common Name | PD-85639 | ||
|---|---|---|---|---|
| CAS Number | 149838-21-1 | Molecular Weight | 365.51200 | |
| Density | 1.06g/cm3 | Boiling Point | 562.1ºC at 760 mmHg | |
| Molecular Formula | C23H31N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 293.8ºC | |
Use of PD-85639PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membranes) and a fast kinetic (t1/2 = 1.2 at 4°C, <0.5 min at 25°C), competitive against the local anesthetic Na+ channel blockers tetracaine, bupivacaine, and mepivacaine, as well as Na+ channel activators veratridine and batrachotoxin (K1 = 0.26 μM against 5 nM [3H]-BTX for binding rat neocrotical membranes). |
| Name | 2-[3-(2,6-dimethylpiperazin-1-yl)phenyl]-2-phenylpentanamide |
|---|
| Density | 1.06g/cm3 |
|---|---|
| Boiling Point | 562.1ºC at 760 mmHg |
| Molecular Formula | C23H31N3O |
| Molecular Weight | 365.51200 |
| Flash Point | 293.8ºC |
| Exact Mass | 365.24700 |
| PSA | 59.35000 |
| LogP | 4.98820 |
| Vapour Pressure | 1.16E-12mmHg at 25°C |
| Index of Refraction | 1.552 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: PD-85639
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/500mg
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: PD-85639
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: PD-85639
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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