Quinestrol
Modify Date: 2024-01-04 18:28:13
Quinestrol structure
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Common Name | Quinestrol | ||
|---|---|---|---|---|
| CAS Number | 152-43-2 | Molecular Weight | 364.520 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 502.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H32O2 | Melting Point | 107 - 108ºC | |
| MSDS | Chinese USA | Flash Point | 218.8±24.4 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of QuinestrolQuinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer |
| Name | quinestrol |
|---|---|
| Synonym | More Synonyms |
| Description | Quinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer |
|---|---|
| Related Catalog |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.5±50.0 °C at 760 mmHg |
| Melting Point | 107 - 108ºC |
| Molecular Formula | C25H32O2 |
| Molecular Weight | 364.520 |
| Flash Point | 218.8±24.4 °C |
| Exact Mass | 364.240234 |
| PSA | 29.46000 |
| LogP | 6.67 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.596 |
|
Revision number: 5
Quinestrol SAFETY DATA SHEET Section1. IDENTIFICATION Quinestrol Product name: 5 Revision number: Section2. HAZARDS IDENTIFICATION GHS classification Not classified PHYSICAL HAZARDS HEALTH HAZARDS Category 2 Carcinogenicity Not classified ENVIRONMENTAL HAZARDS GHS label elements, including precautionary statements Pictograms or hazard symbols Warning Signal word Suspected of causing cancer Hazard statements Precautionary statements: Obtain special instructions before use. [Prevention] Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. [Response] Store locked up. [Storage] Dispose of contents/container through a waste management company authorized by [Disposal] the local government. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance Substance/mixture: Quinestrol Components: >97.0%(LC)(T) Percent: 152-43-2 CAS Number: 17α-Ethynylestradiol 3-Cyclopentyl Ether Synonyms: C25H32O2 Chemical Formula: Section4. FIRST AID MEASURES Remove victim to fresh air and keep at rest in a position comfortable for breathing. Inhalation: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Gently wash with plenty of Skin contact: soap and water. Get medical advice/attention. Quinestrol Section4. FIRST AID MEASURES Rinse cautiously with water for several minutes. Remove contact lenses, if present Eye contact: and easy to do. Get medical advice/attention. Get medical advice/attention.Rinse mouth. Ingestion: A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles. Section5. FIRE-FIGHTING MEASURES Dry chemical, foam, water spray, carbon dioxide. Suitable extinguishing media: Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. When extinguishing fire, be sure to wear personal protective equipment. Special protective equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep Personal precautions, protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should emergency procedures: be controlled around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Handling is performed in a well ventilated place. Wear suitable protective equipment. Technical measures: Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid all contact! Conditions for safe storage, including any incompatibilities Keep container tightly closed. Store in a cool and dark place. Storage conditions: Store locked up. Store away from incompatible materials such as oxidizing agents. Comply with laws. Packaging material: Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Install a closed system or local exhaust. Also install safety shower and eye bath. Engineering controls: Personal protective equipment Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations. Impervious gloves. Hand protection: Safety goggles. A face-shield, if the situation requires. Eye protection: Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Solid Physical state (20°C): Crystal- Powder Form: White - Almost white Colour: No data available Odour: pH: No data available Melting point/freezing point:110°C Quinestrol Section9. PHYSICAL AND CHEMICAL PROPERTIES No data available Boiling point/range: No data available Flash point: Flammability or explosive limits: No data available Lower: No data available Upper: No data available Relative density: Solubility(ies): No data available [Water] [Other solvents] Dioxane Soluble: Section10. STABILITY AND REACTIVITY Stable under proper conditions. Chemical stability: Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide products: Section11. TOXICOLOGICAL INFORMATION No data available Acute Toxicity: Skin corrosion/irritation: No data available No data available Serious eye damage/irritation: No data available Germ cell mutagenicity: Carcinogenicity: No data available IARC = No data available NTP = No data available Reproductive toxicity: RC8948000 RTECS Number: Section12. ECOLOGICAL INFORMATION Ecotoxicity: No data available Fish: No data available Crustacea: No data available Algae: Persistence / degradability: No data available No data available Bioaccumulative potential(BCF): Mobility in soil No data available Log Pow: No data available Soil adsorption (Koc): No data available Henry's Law constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Does not correspond to the classification standard of the United Nations Hazards Class: Not listed UN-No: Quinestrol Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H312-H332-H350-H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R46;R61;R20/21/22 |
| Safety Phrases | S53-S22-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RC8948000 |
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~%
Quinestrol CAS#:152-43-2 |
| Literature: Steroids, , vol. 2, p. 387 - 392 |
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~%
Quinestrol CAS#:152-43-2 |
| Literature: Gazzetta Chimica Italiana, , vol. 93, p. 1503 - 1519 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
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The bioaccumulation and biotransformation of synthetic estrogen quinestrol in crucian carp.
Aquat. Toxicol. 155 , 84-90, (2014) The occurrence and fate of endocrine disrupting chemicals (EDCs) in aquatic species have attracted close attention during the last decades. In this study, the bioaccumulation and biotransformation of ... |
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Photodegradation of quinestrol in waters and the transformation products by UV irradiation.
Chemosphere 89(11) , 1419-25, (2012) Quinestrol is synthetic estrogen used in contraceptive and hormone replacement therapy and occasionally for treating breast cancer and prostate cancer. It can make its way into the environment through... |
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Effects of quinestrol on reproductive hormone expression, secretion, and receptor levels in female Mongolian gerbils (Meriones unguiculatus).
Theriogenology 77(6) , 1223-31, (2012) Quinestrol, a synthetic estrogen with marked estrogenic effects and prolonged activity, has potential as a contraceptive for Mongolian gerbils. The objective of this study was to describe the effects ... |
| 3-(Cyclopentyloxy)-19-nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol |
| 17a-Ethinylestradiol 3-Cyclopentyl Ether |
| 19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-, (17α)- |
| MFCD00079189 |
| Quinestrol |
| (8R,9S,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol |
| Estra-1(10),2,4-trien-17-ol, 3-(cyclopentyloxy)-17-ethynyl-, (17β)- |
| 17α-Ethynylestradiol 3-Cyclopentyl Ether |
| (17α)-3-(Cyclopentyloxy)-19-norpregna-1(10),2,4-trien-20-yn-17-ol |
| EINECS 205-803-1 |