acenocoumarol

Modify Date: 2024-01-04 11:22:25

acenocoumarol Structure
acenocoumarol structure
Common Name acenocoumarol
CAS Number 152-72-7 Molecular Weight 353.326
Density 1.4±0.1 g/cm3 Boiling Point 592.7±50.0 °C at 760 mmHg
Molecular Formula C19H15NO6 Melting Point 196-199ºC
MSDS Chinese USA Flash Point 312.3±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of acenocoumarol


Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.

 Names

Name acenocoumarol
Synonym More Synonyms

 acenocoumarol Biological Activity

Description Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.
Related Catalog

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 592.7±50.0 °C at 760 mmHg
Melting Point 196-199ºC
Molecular Formula C19H15NO6
Molecular Weight 353.326
Flash Point 312.3±30.1 °C
Exact Mass 353.089935
PSA 113.33000
LogP 3.15
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.656
Water Solubility DMSO, heptane and xylene: ≥17mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN4900000
CHEMICAL NAME :
Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-
CAS REGISTRY NUMBER :
152-72-7
LAST UPDATED :
199504
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H15-N-O6
MOLECULAR WEIGHT :
353.35
WISWESSER LINE NOTATION :
T66 BOVJ DY1V1&R DNW& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
513 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,3,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 11,85,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
24 mg/kg
SEX/DURATION :
female 1-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 36,63,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7380 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 239 (estimated) No. of Female Employees: 157 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 63-22-36/37/38
Safety Phrases 26-36/37
RIDADR UN 2811
RTECS GN4900000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2932209090

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

UNII:I6WP63U32H
4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Trombostop
EINECS 205-807-3
MFCD00137816
2H-1-Benzopyran-2-one, 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-
2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-
2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-, (±)-
3-(a-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin
4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one
acenocoumarol
3-(a-p-Nitrophenyl-b-acetylethyl)-4-hydroxycoumarin
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