Sophoricoside
Sophoricoside structure
|
Common Name | Sophoricoside | ||
|---|---|---|---|---|
| CAS Number | 152-95-4 | Molecular Weight | 432.378 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 763.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H20O10 | Melting Point | 285ºC | |
| MSDS | Chinese USA | Flash Point | 271.5±26.4 °C | |
Use of SophoricosideSophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Sophoricoside |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. |
|---|---|
| Related Catalog | |
| In Vitro | Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner[1]. |
| In Vivo | When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent[1]. |
| Kinase Assay | Cells are incubated with the Sophoricoside for 1 h, and then incubated with PMACI for 2 h. The reaction is stopped by cooling the tubes in ice. The cells are separated from the released histamine by centrifugation at 400×g for 5 min at 4°C. The histamine levels are measured by ELISA using a histamine assay kit according to the manufacturer’s directions. Duplicate aliquots of supernatant are measured for each sample[1]. |
| Cell Assay | To test the cell viability by each concentration of Sophoricoside, the MTT colorimetric assay is performed. Briefly, HMC-1 cells (3×105 cells/well) are incubated with Sophoricoside (1 to 50 μM) for 12 h. After the addition of MTT solution, the cells are incubated at 37°C for 4 h. The crystallized MTT (formazan) is dissolved in dimethyl sulfoxide and the absorbance is measured at 540 nm[1]. |
| Animal Admin | BALB/c mice (5 weeks, 19 to 20 g) are used in this study. The dorsal skin of the BALB/c mice (n=6) is shaved and treated with a depilatory prior to the experiment. The mice are sensitized with 100 μL of 0.15% DNCB in acetone-olive oil (3:1) applied to the dorsal skin twice per week for 5 weeks. Control mice receive vehicle (acetone/olive oil=3:1). After 3 weeks, Sophoricoside (2 mg/kg) is orally administered 2 weeks until the end of the experiment[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 763.3±60.0 °C at 760 mmHg |
| Melting Point | 285ºC |
| Molecular Formula | C21H20O10 |
| Molecular Weight | 432.378 |
| Flash Point | 271.5±26.4 °C |
| Exact Mass | 432.105652 |
| PSA | 170.05000 |
| LogP | 0.31 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.717 |
| InChIKey | ISQRJFLLIDGZEP-CMWLGVBASA-N |
| SMILES | O=c1c(-c2ccc(OC3OC(CO)C(O)C(O)C3O)cc2)coc2cc(O)cc(O)c12 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | T,C |
|---|---|
| Risk Phrases | R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36-S45-S24/25 |
| RIDADR | UN 3276 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AL7970000 |
| Packaging Group | II |
| Hazard Class | 8 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~%
Sophoricoside CAS#:152-95-4 |
| Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 4, p. 383,384, 386 |
|
~%
Sophoricoside CAS#:152-95-4 |
| Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 4, p. 383,384, 386 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
|---|---|
| DownStream 3 | |
CAS#:34086-51-6![[4-(5,7-diacetyloxy-4-oxochromen-3-yl)phenyl] acetate structure](https://image.chemsrc.com/caspic/359/5995-97-1.png)
CAS#:5995-97-1This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-(5,7-Dihydroxy-4-oxo-4H-chromen-3-yl)phenyl β-D-glucopyranoside |
| Genistein-4'-glucoside |
| Genistein 4'-Glucoside |
| 4'-(β-D-Glucopyranosyloxy)-5,7-dihydroxyisoflavone |
| 4H-1-Benzopyran-4-one,3-[4-( |
| 4',5,7-Trihydroxyisoflavone-4'-D-glucoside |
| MFCD01075138 |
| Sophoricoside |
| 3-[4-(b-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-411-1-benzopyran-4-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of Sophoricoside? |
| A: The English name of Sophoricoside is Sophoricoside. |
| Q: What are the uses of Sophoricoside? |
| A: Main uses of Sophoricoside: Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. |
| Q: What are the upstream materials of Sophoricoside? |
| A: Related upstream materials(CAS) of Sophoricoside: 446-72-0;874532-59-9. |
| Q: What is the polar surface area (PSA) of Sophoricoside? |
| A: Polar surface area (PSA) of Sophoricoside is 170.05000. |
| Q: What is the SMILES notation of Sophoricoside? |
| A: SMILES notation of Sophoricoside is O=c1c(-c2ccc(OC3OC(CO)C(O)C(O)C3O)cc2)coc2cc(O)cc(O)c12. |
| Q: What are the downstream products of Sophoricoside? |
| A: Related downstream products(CAS) of Sophoricoside: 34086-51-6;446-72-0;5995-97-1. |
| Q: What is the melting point of Sophoricoside? |
| A: Melting point of Sophoricoside is 285ºC. |
| Q: What is the InChIKey of Sophoricoside? |
| A: InChIKey of Sophoricoside is ISQRJFLLIDGZEP-CMWLGVBASA-N. |
| Q: What is the molecular weight of Sophoricoside? |
| A: Molecular weight of Sophoricoside is 432.378. |
| Q: What English synonyms does Sophoricoside have? |
| A: English synonyms of Sophoricoside: 4-(5,7-Dihydroxy-4-oxo-4H-chromen-3-yl)phenyl β-D-glucopyranoside, Genistein-4'-glucoside, Genistein 4'-Glucoside, 4'-(β-D-Glucopyranosyloxy)-5,7-dihydroxyisoflavone, 4H-1-Benzopyran-4-one,3-[4-(, 4',5,7-Trihydroxyisoflavone-4'-D-glucoside, MFCD01075138, Sophoricoside, 3-[4-(b-D-Glucopyranosyloxy)phenyl]-5,7-dihydroxy-411-1-benzopyran-4-one. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |