Cyclocurcumin

Modify Date: 2024-01-05 10:39:12

Cyclocurcumin structure	Common Name	Cyclocurcumin
	CAS Number	153127-42-5	Molecular Weight	368.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cyclocurcumin

Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities[1][2][3].

Name	cyclocurcumin(p)
Synonym	More Synonyms

Description	Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
In Vitro	Cyclocurcumin (10-40 μM; 18 h) 导致 LPS 刺激的人巨噬细胞中 TNF-α 释放呈剂量依赖性显著抑制[1]。 Cyclocurcumin (5-25 μM) 对新分离大鼠主动脉环苯肾上腺素 (HY-B0769) 诱导的血管收缩呈浓度依赖性 (IC50=14.9±1.0 μM)[2]。 Cyclocurcumin (5-25 μM; 30 min) 以剂量依赖的方式抑制细胞内钙的内流。Cyclocurcumin 以浓度依赖的方式抑制 l 型钙通道介导的血管收缩。Cyclocurcumin 的抗收缩作用是可逆的[2]。 Cyclocurcumin 具有很强的清除 ˙OH 和 ˙OOH 自由基的活性，其 4 ' -OH 酚自由基通过水中和生理环境中的原子转移机制优先清除 ˙OH 和 ˙OOH 自由基[3]。
References	[1]. Fu M, et al. Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. Int J Mol Med. 2017 May;39(5):1164-1172. [2]. Kim K, et al. Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric). J Nat Prod. 2017 Jan 27;80(1):196-200. [3]. Li Y, et al. Antioxidant properties and free radical scavenging mechanisms of cyclocurcumin. New Journal of Chemistry, 2018, 42(15): 12698-12705.

Molecular Formula	C₂₁H₂₀O₆
Molecular Weight	368.38
Exact Mass	368.12600
PSA	85.22000
LogP	3.74280

Hazard Codes	Xi

Cyclocurcumin

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Product Name: Cyclocurcumin
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