Sibenadet hydrochloride

Modify Date: 2024-01-08 23:07:40

Sibenadet hydrochloride Structure
Sibenadet hydrochloride structure
Common Name Sibenadet hydrochloride
CAS Number 154189-24-9 Molecular Weight 501.05900
Density N/A Boiling Point 717ºC at 760mmHg
Molecular Formula C22H29ClN2O5S2 Melting Point N/A
MSDS N/A Flash Point 387.4ºC

 Use of Sibenadet hydrochloride


Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

 Names

Name 4-hydroxy-7-[2-[2-[3-(2-phenylethoxy)propylsulfonyl]ethylamino]ethyl]-3H-1,3-benzothiazol-2-one,hydrochloride
Synonym More Synonyms

 Sibenadet hydrochloride Biological Activity

Description Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.
Related Catalog
References

[1]. Ind PW, Laitinen L, Laursen L, et al. Early clinical investigation of Viozan (sibenadet HCl), a novel D2 dopamine receptor, beta2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms. Respir Med. 2003;97 Suppl A:S9-S21.

 Chemical & Physical Properties

Boiling Point 717ºC at 760mmHg
Molecular Formula C22H29ClN2O5S2
Molecular Weight 501.05900
Flash Point 387.4ºC
Exact Mass 500.12100
PSA 145.11000
LogP 4.76520
Vapour Pressure 3.06E-21mmHg at 25°C

 Synonyms

Sibenadet HCl
Sibenadet hydrochloride
Viozan