Sodium butyrate

Modify Date: 2024-01-02 18:48:33

Sodium butyrate Structure
Sodium butyrate structure
 Common Name Sodium butyrate
CAS Number 156-54-7 Molecular Weight 110.087
Density 0.987g/cm3 Boiling Point 164.3ºC at 760 mmHg
Molecular Formula C4H7NaO2 Melting Point 250-253 °C(lit.)
MSDS Chinese USA Flash Point 69.7ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Sodium butyrate


Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

 Names

Name sodium butyrate
Synonym More Synonyms

 Sodium butyrate Biological Activity

Description Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.
Related Catalog
Target

HDAC

In Vitro Sodium Butyrate induces morphological changes, inhibits cell proliferation and impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- and time-dependent decrease in cell viability, in both 5-8F and 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition and disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate[1]. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR and PCNA protein. Sodium butyrate, in a dose-dependent manner, induces cell cycle arrest in G0/G1 phase and reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, and pro-apoptosis bak genes, and protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, and Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), and the levels of cyclinD1 and CDK6 are reduced by 5 and 10 mM butyrate[3].
In Vivo Sodium Butyrate (300 mg/kg, s.c.) administration immediately after HI provided almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate administration results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia[2]. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes[4].
Cell Assay Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 µL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 µL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 µL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.
Animal Admin Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days.
References

[1]. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929

[2]. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34

[3]. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27

[4]. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230

[5]. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.

 Chemical & Physical Properties

Density 0.987g/cm3
Boiling Point 164.3ºC at 760 mmHg
Melting Point 250-253 °C(lit.)
Molecular Formula C4H7NaO2
Molecular Weight 110.087
Flash Point 69.7ºC
Exact Mass 110.034370
PSA 40.13000
Vapour Pressure 1.35mmHg at 25°C
Stability Stable. Incompatible with strong acids.
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ET6400000
CHEMICAL NAME :
Butyric acid, sodium salt
CAS REGISTRY NUMBER :
156-54-7
LAST UPDATED :
199803
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C4-H8-O2.Na
MOLECULAR WEIGHT :
111.11
WISWESSER LINE NOTATION :
OV3 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Mammal - cattle Lymphocyte
DOSE/DURATION :
4 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,141,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82158 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 184 (estimated) No. of Female Employees: 101 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26-S24/25
RIDADR 2820
WGK Germany 1
RTECS ET6400000
HS Code 2915600000

 Customs

HS Code 2915600000
Summary 2915600000 butanoic acids and pentanoic acids and their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles145

More Articles
Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

PLoS Biol. 12(1) , e1001758, (2014)

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of ep...

Short-chain fatty acids and acidic pH upregulate UT-B, GPR41, and GPR4 in rumen epithelial cells of goats.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(4) , R283-93, (2015)

Currently, the mechanism(s) responsible for the regulation of urea transporter B (UT-B) expression levels in the epithelium of the rumen remain unclear. We hypothesized that rumen fermentation product...

The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

J. Mol. Biol. 426(24) , 3960-72, (2014)

In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional r...

 Synonyms

MFCD00002816
Butyrate sodium salt
Natriumbutyrat
Na butyrate
EINECS 205-857-6
SODIUM BUTYRATE pure
NAB
BUTYRIC ACID NA
Sodium butanoate
SODIUM N-BUTYLATE
SODIUMBUTYRATE,USP
Sodium Butyrate
sodium n-butyrate
butyratesodium
butyric acid sodium salt
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Sodium butyrate suppliers

Price: $55/10mM*1mLinWater

Reference only. check more Sodium butyrate price

Related Compounds: More...
sodium butyrate-d7
270564-49-3
SodiuM Butyrate--d3
347840-05-5
SodiuM Butyrate--d5
204244-79-1
Sodium butyrate-13C4
312623-84-0
Sodium butyrate-2-13C
286367-62-2
Sodium butyrate-4-13C
286367-75-7
Sodium butyrate-4-13C
53736-52-0
Sodium butyrate-1-13C
62601-04-1
Sodium butyrate-1,2-13C2
286367-74-6
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(2-(3-((4-chlorophenyl)sulfonyl)azetidin-1-yl)-2-oxoethyl)benzamide
1797887-76-3
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
2-(2-methoxyphenoxy)-N-((1-methyl-1,4,6,7-tetrahydropyrano[4,3-c]pyrazol-3-yl)methyl)acetamide
1797681-56-1
tert-Butyl-DL-alanine
1375289-11-4
Chemsrc provides Sodium butyrate(CAS#:156-54-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sodium butyrate are included as well.>> amp version: Sodium butyrate

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved