1-Ethynylnaphthalene

Modify Date: 2024-01-02 11:50:49

1-Ethynylnaphthalene Structure
1-Ethynylnaphthalene structure
Common Name 1-Ethynylnaphthalene
CAS Number 15727-65-8 Molecular Weight 152.19200
Density 1.070 g/mL at 25ºC(lit.) Boiling Point 270.4ºC at 760 mmHg
Molecular Formula C12H8 Melting Point N/A
MSDS N/A Flash Point 106.3ºC

 Use of 1-Ethynylnaphthalene


1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.

 Names

Name 1-ethynylnaphthalene
Synonym More Synonyms

 1-Ethynylnaphthalene Biological Activity

Description 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
Related Catalog
Target

P450 1B1[1]

In Vitro 1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].
References

[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.

 Chemical & Physical Properties

Density 1.070 g/mL at 25ºC(lit.)
Boiling Point 270.4ºC at 760 mmHg
Molecular Formula C12H8
Molecular Weight 152.19200
Flash Point 106.3ºC
Exact Mass 152.06300
LogP 2.82110
Vapour Pressure 0.0114mmHg at 25°C
Index of Refraction n20/D 1.6500(lit.)
Storage condition 2-8℃

 Safety Information

Risk Phrases R10
Safety Phrases 16
RIDADR UN 1993 3
HS Code 2902909090

 Synthetic Route

 Customs

HS Code 2902909090
Summary 2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

 Synonyms

1-(ethynyl)naphthalene
1-naphthalene-acetylene
Naphthalene,1-ethynyl
naphthylacetylene
(1-naphthyl)acetylene
MFCD02093737
ethynyl-naphthalene