RAS activator compound 1
Modify Date: 2025-11-07 19:30:23
RAS activator compound 1 structure
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Common Name | RAS activator compound 1 | ||
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| CAS Number | 1579978-17-8 | Molecular Weight | 449.983 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H28ClN5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RAS activator compound 1RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2. |
| Name | RAS activator compound 1 |
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| Description | RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2. |
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| References | References 1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060. 2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. View Related Products by Target Ras |
| Molecular Formula | C25H28ClN5O |
|---|---|
| Molecular Weight | 449.983 |
| InChIKey | LMAYILTVNBZXSW-JOCHJYFZSA-N |
| SMILES | NC(Cc1c[nH]c2ccccc12)C(=O)NC1CCN(Cc2c[nH]c3ccc(Cl)cc23)CC1 |