1579978-17-8
1579978-17-8 structure
- Name: RAS activator compound 1
- Chemical Name: RAS activator compound 1
- CAS Number: 1579978-17-8
- Molecular Formula: C25H28ClN5O
- Molecular Weight: 449.983
- Create Date: 2020-01-12 13:42:01
- Modify Date: 2024-01-22 19:48:26
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RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.
| Name | RAS activator compound 1 |
|---|
| Description | RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2. |
|---|---|
| References | References 1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060. 2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. View Related Products by Target Ras |
| Molecular Formula | C25H28ClN5O |
|---|---|
| Molecular Weight | 449.983 |