Mc-Val-Cit-PABC-PNP

Modify Date: 2024-01-09 19:40:08

Mc-Val-Cit-PABC-PNP Structure
Mc-Val-Cit-PABC-PNP structure
Common Name Mc-Val-Cit-PABC-PNP
CAS Number 159857-81-5 Molecular Weight 737.756
Density 1.3±0.1 g/cm3 Boiling Point 1034.5±65.0 °C at 760 mmHg
Molecular Formula C35H43N7O11 Melting Point N/A
MSDS N/A Flash Point 579.4±34.3 °C

 Use of Mc-Val-Cit-PABC-PNP


Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name MC-Val-Cit-PABC-PNP
Synonym More Synonyms

 Mc-Val-Cit-PABC-PNP Biological Activity

Description Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
References

[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1034.5±65.0 °C at 760 mmHg
Molecular Formula C35H43N7O11
Molecular Weight 737.756
Flash Point 579.4±34.3 °C
Exact Mass 737.302063
PSA 261.15000
LogP 2.71
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.599
Storage condition 2~8℃

 Synthetic Route

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Mc-Val-Cit-PABC-PNP Structure

Mc-Val-Cit-PABC-PNP

CAS#:159857-81-5

Literature: WO2007/8603 A1, ; Page/Page column 137; 166; 167 ;

 Synonyms

maleimidocaproyl-val-Cit-PAB-OCOpNP
N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl)carbonate
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
maleimido-caproyl-valine-citrulline-para-aminobenzyl-4-nitrophenylcarbonate
MC-VAL-CIT-PAB-PNB
Mc-Val-Cit-PABC-PNP
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Price: $251/10mM*1mLinDMSO

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