Diethyl pyrocarbonate

Modify Date: 2026-07-02 17:30:12

Diethyl pyrocarbonate Structure
Diethyl pyrocarbonate structure
 Common Name Diethyl pyrocarbonate
CAS Number 1609-47-8 Molecular Weight 162.141
Density 1.2±0.1 g/cm3 Boiling Point 201.3±9.0 °C at 760 mmHg
Molecular Formula C6H10O5 Melting Point N/A
MSDS Chinese USA Flash Point 69.4±0.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Diethyl pyrocarbonate


Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name diethyl pyrocarbonate
Synonym More Synonyms

 Diethyl pyrocarbonate Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues[1].
Related Catalog
References

[1]. E E Nattie. Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. J Appl Physiol (1985). 1986 Sep;61(3):843-50.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.2±0.1 g/cm3
Boiling Point 201.3±9.0 °C at 760 mmHg
Molecular Formula C6H10O5
Molecular Weight 162.141
Flash Point 69.4±0.0 °C
Exact Mass 162.052826
PSA 61.83000
LogP 1.48
Vapour Pressure 0.3±0.4 mmHg at 25°C
Index of Refraction 1.413
InChIKey FFYPMLJYZAEMQB-UHFFFAOYSA-N
SMILES CCOC(=O)OC(=O)OCC
Storage condition 2-8°C
Stability Combustible. Unstable - readily decomposes. Incompatible with strong oxidizing agents, strong acids, strong reducing agents, strong bases, ammonia.
Water Solubility slow decomposition

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ9350000
CHEMICAL NAME :
Formic acid, oxydi-, diethyl ester
CAS REGISTRY NUMBER :
1609-47-8
BEILSTEIN REFERENCE NO. :
0637031
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C6-H10-O5
MOLECULAR WEIGHT :
162.16
WISWESSER LINE NOTATION :
2OVOVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZLUFAR Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.86- 1943- Volume(issue)/page/year: 114,292,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1558 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR 2810
WGK Germany 3
RTECS LQ9350000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2920909090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2920909090
Summary 2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles196

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

The effects of triclosan on pluripotency factors and development of mouse embryonic stem cells and zebrafish.

Arch. Toxicol. 89(4) , 635-46, (2015)

Triclosan (TCS) poses potential risks to reproduction and development due to its endocrine-disrupting properties. However, the mechanism of TCS's effects on early embryonic development is little known...

Unbinding forces and energies between a siRNA molecule and a dendrimer measured by force spectroscopy.

Nanoscale 7 , 20267-76, (2015)

We have measured the intermolecular forces between small interference RNA (siRNA) and polyamidoamine dendrimers at the single molecular level. A single molecule force spectroscopy approach has been de...

Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells.

Pharm. Biol. 52(11) , 1451-9, (2014)

Abstract Background: Carbamazepine, which was developed primarily for the treatment of epilepsy, is now also useful for the treatment of non-epileptic disorders and inflammatory hyperalgesia. However,...

 Diethyl pyrocarbonateBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of human ACAT1
Source: ChEMBL
Target: Sterol O-acyltransferase 1
External Id: CHEMBL3882627
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Selectivity ratio of IC50 for human ACAT2 to IC50 for human ACAT1
Source: ChEMBL
Target: N/A
External Id: CHEMBL3882629
Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788
Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Total 129, Current Page 1 of 13
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Diethyl pyrocarbonate
MFCD00009106
ethoxycarbonyl ethyl carbonate
diethyl dicarbonate
DEP,DEPC,Diethyl dicarbonate
Diethyl pyrocarbonate (DEPC)
Diethyl oxydiformate
Ethoxyformic acid anhydride
EINECS 216-542-8

 Diethyl pyrocarbonate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of diethyl pyrocarbonate?
A: Boiling point of diethyl pyrocarbonate is 201.3±9.0 °C at 760 mmHg.
Q: What are the storage conditions for diethyl pyrocarbonate?
A: Storage conditions for diethyl pyrocarbonate: 2-8°C.
Q: What is the molecular formula of diethyl pyrocarbonate?
A: Molecular formula of diethyl pyrocarbonate is C6H10O5.
Q: What are the downstream products of diethyl pyrocarbonate?
A: Related downstream products(CAS) of diethyl pyrocarbonate: 424-36-2;544-35-4;41430-70-0;32996-16-0;93-89-0;14619-42-2;180468-42-2;94-30-4;1847-84-3.
Q: What is the safety information for diethyl pyrocarbonate?
A: Safety information for diethyl pyrocarbonate: S26-S36-S37/39.
Q: What are the uses of diethyl pyrocarbonate?
A: Main uses of diethyl pyrocarbonate: Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues[1].
Q: What English synonyms does diethyl pyrocarbonate have?
A: English synonyms of diethyl pyrocarbonate: Diethyl pyrocarbonate, MFCD00009106, ethoxycarbonyl ethyl carbonate, diethyl dicarbonate, DEP,DEPC,Diethyl dicarbonate, Diethyl pyrocarbonate (DEPC), Diethyl oxydiformate, Ethoxyformic acid anhydride, EINECS 216-542-8.
Q: What is the English name of diethyl pyrocarbonate?
A: The English name of diethyl pyrocarbonate is diethyl pyrocarbonate.
Q: What is the CAS number of diethyl pyrocarbonate?
A: CAS number of diethyl pyrocarbonate is 1609-47-8.
Q: What is the molecular weight of diethyl pyrocarbonate?
A: Molecular weight of diethyl pyrocarbonate is 162.141.

 Diethyl pyrocarbonatefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Diethyl pyrocarbonate(CAS#:1609-47-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Diethyl pyrocarbonate are included as well.>> amp version: Diethyl pyrocarbonate

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