NNGH
NNGH structure
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Common Name | NNGH | ||
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| CAS Number | 161314-17-6 | Molecular Weight | 316.373 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H20N2O5S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of NNGHNNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression[1]. |
| Name | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID |
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| Synonym | More Synonyms |
| Description | NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C13H20N2O5S |
| Molecular Weight | 316.373 |
| Exact Mass | 316.109283 |
| LogP | 1.94 |
| Index of Refraction | 1.547 |
| Storage condition | 2-8°C |
| RIDADR | NONH for all modes of transport |
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Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress.
PLoS ONE 9(12) , e115954, (2014) In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation ca... |
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Matrix Metalloproteinase-3 Promotes Early Blood–Spinal Cord Barrier Disruption and Hemorrhage and Impairs Long-Term Neurological Recovery after Spinal Cord Injury
Am. J. Pathol. 184(11) , 2985-3000, (2014) After spinal cord injury (SCI), blood–spinal cord barrier (BSCB) disruption by matrix metalloproteinases (MMPs) leads to BSCB permeability and blood cell infiltration, contributing to permanent neurol... |
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Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine.
Dev. Biol. 403 , 43-56, (2015) Hox cluster genes play crucial roles in development of the metazoan antero-posterior axis. Functions of Hox genes in patterning the central nervous system and limb buds are well known. They are also e... |
| Acetamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]- |
| N-Hydroxy-N2-isobutyl-N2-[(4-methoxyphenyl)sulfonyl]glycinamide |
| N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID |