Esomeprazole

Modify Date: 2024-01-02 18:03:19

Esomeprazole Structure
Esomeprazole structure
Common Name Esomeprazole
CAS Number 161973-10-0 Molecular Weight 713.121
Density N/A Boiling Point 600ºC at 760 mmHg
Molecular Formula C34H36MgN6O6S2 Melting Point N/A
MSDS N/A Flash Point 316.7ºC

 Use of Esomeprazole


Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.

 Names

Name esomeprazole magnesium
Synonym More Synonyms

 Esomeprazole Biological Activity

Description Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.
Related Catalog
Target

H+, K+-ATPase[1]

In Vitro Esomeprazole magnesium is an inhibitor of H+, K+-ATPase[1].
In Vivo Esomeprazole magnesium (0.5, 5, 50 mg/kg/day, p.o.) produces increased gastric total antioxidant capacity, decreases gastric lipid peroxide levels, significantly increases superoxide dismutase levels, but shows no obvious effect on colonic lipid peroxide levels in mice[1].
Animal Admin Mice[1] In this 10-day supplementation experiment, mice (n = 10/group) receive the following: 1) as a control group, only the vehicle for dissolution of Esomeprazole (PEG-400) given orally once daily by gastric gavage; 2) Esomeprazole 0.5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; 3) Esomeprazole 5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; and 4) Esomeprazole 50 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage[1].
References

[1]. Koch TR, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

 Chemical & Physical Properties

Boiling Point 600ºC at 760 mmHg
Molecular Formula C34H36MgN6O6S2
Molecular Weight 713.121
Flash Point 316.7ºC
Exact Mass 712.198792
PSA 186.82000
LogP 6.78900
Vapour Pressure 2.35E-14mmHg at 25°C
Storage condition -20℃

 Synonyms

(-)-Omeprazole magnesium
Nexium
H-199/18
omeprazole magnesium
EsMeprazole Magne-siuM Trihydrate
sulfonium, hydroxy(6-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-, inner salt, magnesium salt (2:1)
H 199/18
(T-4-(S),(S))-Bis(5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazolato)magnesium
(S)-Omeprazole magnesium
(T-4)-Bis(5-methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl-kO)-1H-benzimidazolato-kN1)magnesium
Magnesium bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}benzimidazol-1-ide)
Esomeprazole magnesium
1H-Benzimidazole, 5-methoxy-2-[(S)-[(1S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, magnesium salt (2:1)
Magnesium bis{(6-methoxybenzimidazol-1-id-2-yl)[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfoniumolate}
Magnesium bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide)
Esomeprazole
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