Vilazodone Hydrochloride
Modify Date: 2025-08-21 12:53:16
Vilazodone Hydrochloride structure
|
Common Name | Vilazodone Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 163521-08-2 | Molecular Weight | 477.98600 | |
| Density | N/A | Boiling Point | 745.1ºC at 760 mmHg | |
| Molecular Formula | C26H28ClN5O2 | Melting Point | 279°C(lit.) | |
| MSDS | Chinese USA | Flash Point | 404.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Vilazodone HydrochlorideVilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. |
| Name | vilazodone hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. |
|---|---|
| Related Catalog | |
| Target |
5-HT1A Receptor |
| In Vivo | Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone (55 mg/kg po) at 120 and 210 min post dose. Vilazodone (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone also represents another option for the treatment of MDD[2]. |
| References |
| Boiling Point | 745.1ºC at 760 mmHg |
|---|---|
| Melting Point | 279°C(lit.) |
| Molecular Formula | C26H28ClN5O2 |
| Molecular Weight | 477.98600 |
| Flash Point | 404.4ºC |
| Exact Mass | 477.19300 |
| PSA | 103.28000 |
| LogP | 5.71868 |
| Appearance of Characters | white to beige |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble20mg/mL, clear |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| Vilazodone HCl |
| 2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1) |
| Vilazodone hydrochloride |
| vilazodone monohydrochloride |
| Vilazodone (Hydrochloride) |
| Viibryd |
| 5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide hydrochloride (1:1) |
| 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide,hydrochloride |
| UNII-U8HTX2GK8J |
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