Vilazodone Hydrochloride

Modify Date: 2025-08-21 12:53:16

Vilazodone Hydrochloride Structure
Vilazodone Hydrochloride structure
 Common Name Vilazodone Hydrochloride
CAS Number 163521-08-2 Molecular Weight 477.98600
Density N/A Boiling Point 745.1ºC at 760 mmHg
Molecular Formula C26H28ClN5O2 Melting Point 279°C(lit.)
MSDS Chinese USA Flash Point 404.4ºC
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Use of Vilazodone Hydrochloride


Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.

 Names

Name vilazodone hydrochloride
Synonym More Synonyms

 Vilazodone Hydrochloride Biological Activity

Description Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.
Related Catalog
Target

5-HT1A Receptor

In Vivo Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone (55 mg/kg po) at 120 and 210 min post dose. Vilazodone (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone also represents another option for the treatment of MDD[2].
References

[1]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

[2]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME.The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder.Curr Med Res Opin. 2012 Jan;28(1):27-39.

 Chemical & Physical Properties

Boiling Point 745.1ºC at 760 mmHg
Melting Point 279°C(lit.)
Molecular Formula C26H28ClN5O2
Molecular Weight 477.98600
Flash Point 404.4ºC
Exact Mass 477.19300
PSA 103.28000
LogP 5.71868
Appearance of Characters white to beige
Storage condition ?20°C
Water Solubility DMSO: soluble20mg/mL, clear

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution

 Synonyms

Vilazodone HCl
2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1)
Vilazodone hydrochloride
vilazodone monohydrochloride
Vilazodone (Hydrochloride)
Viibryd
5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide hydrochloride (1:1)
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide,hydrochloride
UNII-U8HTX2GK8J
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