Vilazodone Hydrochloride structure
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Common Name | Vilazodone Hydrochloride | ||
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CAS Number | 163521-08-2 | Molecular Weight | 477.98600 | |
Density | N/A | Boiling Point | 745.1ºC at 760 mmHg | |
Molecular Formula | C26H28ClN5O2 | Melting Point | 279°C(lit.) | |
MSDS | Chinese USA | Flash Point | 404.4ºC | |
Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger |
Use of Vilazodone HydrochlorideVilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. |
Name | vilazodone hydrochloride |
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Synonym | More Synonyms |
Description | Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. |
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Related Catalog | |
Target |
5-HT1A Receptor |
In Vivo | Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone (55 mg/kg po) at 120 and 210 min post dose. Vilazodone (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone also represents another option for the treatment of MDD[2]. |
References |
Boiling Point | 745.1ºC at 760 mmHg |
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Melting Point | 279°C(lit.) |
Molecular Formula | C26H28ClN5O2 |
Molecular Weight | 477.98600 |
Flash Point | 404.4ºC |
Exact Mass | 477.19300 |
PSA | 103.28000 |
LogP | 5.71868 |
Appearance of Characters | white to beige |
Storage condition | ?20°C |
Water Solubility | DMSO: soluble20mg/mL, clear |
Symbol |
GHS02, GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H225-H301 + H311 + H331-H370 |
Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
Hazard Codes | F,T |
Risk Phrases | 11-23/24/25-39/23/24/25 |
Safety Phrases | 7-16-36/37-45 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
Vilazodone HCl |
2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1) |
Vilazodone hydrochloride |
vilazodone monohydrochloride |
Vilazodone (Hydrochloride) |
Viibryd |
5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-1-benzofuran-2-carboxamide hydrochloride (1:1) |
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide,hydrochloride |
UNII-U8HTX2GK8J |