ML 145
Modify Date: 2024-01-21 11:56:00
ML 145 structure
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Common Name | ML 145 | ||
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| CAS Number | 1164500-72-4 | Molecular Weight | 482.572 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H22N2O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 145ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2]. |
| Name | 2-Hydroxy-4-[(4-{(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}butanoyl)amino]benzoic acid |
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| Synonym | More Synonyms |
| Description | ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2]. |
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| Related Catalog | |
| Target |
CXCR8:20.1 nM (IC50) |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H22N2O5S2 |
| Molecular Weight | 482.572 |
| Exact Mass | 482.097015 |
| LogP | 4.38 |
| Index of Refraction | 1.719 |
| 2-Hydroxy-4-[(4-{(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}butanoyl)amino]benzoic acid |
| Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]- |
| 2-Hydroxy-4-[(4-{(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}butanoyl)amino]benzoic acid |