ML 334

Modify Date: 2024-01-08 11:13:11

ML 334 structure	Common Name	ML 334
	CAS Number	1432500-66-7	Molecular Weight	446.50
	Density	1.354±0.06 g/cm3(Predicted)	Boiling Point	693.1±55.0 °C(Predicted)
	Molecular Formula	C₂₆H₂₆N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 334

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].

Name	ML334

Description	ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2
Target	Ki: 1 μM (Keap1)[2]
In Vitro	ML334 (LH601A; 50-100 µM; 6-16 hours; HEK293 cells) treatment increases NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. And also enhances HO-1 mRNA expression between 4- and 7-fold at 6 h, with lesser fold-changes at 16 h[1]. ML334 (LH601A; 50-100 µM; 16 hours; HEK293 cells) treatment induces HO-1 and TRX1 proteins in HEK293 cells[1]. ML334 (LH601A) stimulates NRF2 expression and nuclear translocation in HEK293 cells[1]. RT-PCR[1] Cell Line: HEK293 cells Concentration: 50 μM or 100 µM Incubation Time: 6 hours, 16 hours Result: Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 50 μM or 100 µM Incubation Time: 16 hours Result: Enhanced HO-1 and TRX1 protein expression at 16 h.
References	[1]. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6. [2]. Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43.

Density	1.354±0.06 g/cm3(Predicted)
Boiling Point	693.1±55.0 °C(Predicted)
Molecular Formula	C₂₆H₂₆N₂O₅
Molecular Weight	446.50

DC Chemicals Limited
China
Product Name: ML334
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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ML 334

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