4-hydroxyantipyrine
4-hydroxyantipyrine structure
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Common Name | 4-hydroxyantipyrine | ||
|---|---|---|---|---|
| CAS Number | 1672-63-5 | Molecular Weight | 204.22500 | |
| Density | 1.294g/cm3 | Boiling Point | 314.3ºC at 760mmHg | |
| Molecular Formula | C11H12N2O2 | Melting Point | 184-186ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 143.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 4-hydroxyantipyrine4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. |
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| Related Catalog | |
| In Vitro | 4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1]. 4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.294g/cm3 |
|---|---|
| Boiling Point | 314.3ºC at 760mmHg |
| Melting Point | 184-186ºC(lit.) |
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.22500 |
| Flash Point | 143.9ºC |
| Exact Mass | 204.09000 |
| PSA | 47.16000 |
| LogP | 1.19000 |
| Vapour Pressure | 0.000199mmHg at 25°C |
| Index of Refraction | 1.63 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 7 | |
CAS#:5426-65-3
CAS#:60-80-0
CAS#:58-15-1
CAS#:83-07-8
CAS#:479-92-5
CAS#:620-81-5
CAS#:10605-18-2
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CAS#:38604-70-5![Bernsteinsaeure[bis(1,1'-methyl-2,2'-phenyl)hydrazid-(1,1')] structure](https://image.chemsrc.com/caspic/352/76788-81-3.png)
CAS#:76788-81-3
CAS#:144-62-7This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The effect of age and sex on metabolism and urinary excretion of antipyrine.
J. Gerontol. A. Biol. Sci. Med. Sci. 53(1) , M14-9, (1998) Drug-metabolizing capacity is generally reduced in the elderly. The purpose of this investigation was to study antipyrine clearance and metabolite excretion in old subjects of both sexes.Saliva cleara... |
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The pharmacokinetics of antipyrine and three of its metabolites in the rabbit: intravenous administration of pure metabolites.
Pharm. Res. 8(12) , 1470-6, (1991) Antipyrine (AP) is a commonly used probe of oxidative metabolism. Indirect evidence demonstrates formation rate limited disposition of its metabolites. Kinetic studies using antipyrine and its major m... |
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Separation and identification of the 4-hydroxyantipyrine sulphoconjugate.
J. Chromatogr. A. 576(1) , 103-9, (1992) In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an io... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea...
Source: Broad Institute
Target: histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens]
External Id: 2125-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00003143 |
| 1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on |
| 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one |
| 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one |
| 1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone |
| Prestwick_270 |
| hydroxy-4 antipyrine |
| 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one |
| Antipyrine,4-hydroxy |
| 4-Hydroxyantipyrine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Polar surface area (PSA) of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 47.16000. |
| Q: What is the safety information for 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Safety information for 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one: 26-36. |
| Q: What is the boiling point of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Boiling point of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 314.3ºC at 760mmHg. |
| Q: What is the CAS number of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: CAS number of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 1672-63-5. |
| Q: What is the English name of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: The English name of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one. |
| Q: What English synonyms does 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one have? |
| A: English synonyms of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one: MFCD00003143, 1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on, 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one, 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone, Prestwick_270, hydroxy-4 antipyrine, 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, Antipyrine,4-hydroxy, 4-Hydroxyantipyrine. |
| Q: What is the molecular formula of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Molecular formula of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is C11H12N2O2. |
| Q: What is the LogP of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: LogP of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 1.19000. |
| Q: What are the uses of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Main uses of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one: 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. |
| Q: What is the melting point of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one? |
| A: Melting point of 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one is 184-186ºC(lit.). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |