4-hydroxyantipyrine

Modify Date: 2025-08-25 23:43:30

4-hydroxyantipyrine structure	Common Name	4-hydroxyantipyrine
	CAS Number	1672-63-5	Molecular Weight	204.22500
	Density	1.294g/cm3	Boiling Point	314.3ºC at 760mmHg
	Molecular Formula	C₁₁H₁₂N₂O₂	Melting Point	184-186ºC(lit.)
	MSDS	Chinese USA	Flash Point	143.9ºC
	Symbol	GHS07	Signal Word	Warning

Use of 4-hydroxyantipyrine

4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].

Name	4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one
Synonym	More Synonyms

Description	4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1]. 4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2].
References	[1]. Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24(5):529-34. [2]. Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24(12):1404-10.

Density	1.294g/cm3
Boiling Point	314.3ºC at 760mmHg
Melting Point	184-186ºC(lit.)
Molecular Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.22500
Flash Point	143.9ºC
Exact Mass	204.09000
PSA	47.16000
LogP	1.19000
Vapour Pressure	0.000199mmHg at 25°C
Index of Refraction	1.63

4-hydroxyantipyrine MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 5
CAS#:5426-65-3 3H-Pyrazol-3-on... CAS#:60-80-0 Antipyrine CAS#:58-15-1 aminophenazone CAS#:83-07-8 4-Aminoantipyrine
CAS#:479-92-5 propyphenazone
DownStream 7
CAS#:620-81-5 N,N'-Diphenylet... CAS#:10605-18-2 N-Methyl-N-phen... CAS#:88741-26-8 2-(C,N-dimethyl... CAS#:81416-56-0 (1,5-dimethyl-3...
CAS#:38604-70-5 N-methyl-N-phen... CAS#:76788-81-3 Bernsteinsaeure... CAS#:144-62-7 Oxalic acid

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The effect of age and sex on metabolism and urinary excretion of antipyrine.

J. Gerontol. A. Biol. Sci. Med. Sci. 53(1) , M14-9, (1998)

Drug-metabolizing capacity is generally reduced in the elderly. The purpose of this investigation was to study antipyrine clearance and metabolite excretion in old subjects of both sexes.Saliva cleara...

The pharmacokinetics of antipyrine and three of its metabolites in the rabbit: intravenous administration of pure metabolites.

Pharm. Res. 8(12) , 1470-6, (1991)

Antipyrine (AP) is a commonly used probe of oxidative metabolism. Indirect evidence demonstrates formation rate limited disposition of its metabolites. Kinetic studies using antipyrine and its major m...

Separation and identification of the 4-hydroxyantipyrine sulphoconjugate.

J. Chromatogr. A. 576(1) , 103-9, (1992)

In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an io...

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

Name: EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea...
Source: Broad Institute
Target: histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens]
External Id: 2125-01_Inhibitor_SinglePoint_HTS_Activity

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

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MFCD00003143

1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on

4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone

Prestwick_270

hydroxy-4 antipyrine

1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one

Antipyrine,4-hydroxy

4-Hydroxyantipyrine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Hydroxyantipyrineanalyticalstandard
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Purity: 99.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3H-Pyrazol-3-one,1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Email: enquiry@dycnchem.com

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