propyphenazone

Modify Date: 2024-01-02 13:19:53

propyphenazone Structure
propyphenazone structure
Common Name propyphenazone
CAS Number 479-92-5 Molecular Weight 230.305
Density 1.1±0.1 g/cm3 Boiling Point 319.0±25.0 °C at 760 mmHg
Molecular Formula C14H18N2O Melting Point 102-105°C
MSDS Chinese USA Flash Point 123.8±15.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of propyphenazone


Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target:COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.

 Names

Name propyphenazone
Synonym More Synonyms

 propyphenazone Biological Activity

Description Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target:COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.
Related Catalog
Target

COX

References

[1]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 319.0±25.0 °C at 760 mmHg
Melting Point 102-105°C
Molecular Formula C14H18N2O
Molecular Weight 230.305
Flash Point 123.8±15.5 °C
Exact Mass 230.141907
PSA 26.93000
LogP 1.74
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.556
Storage condition Refrigerator
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CD2800000
CHEMICAL NAME :
Antipyrine, 4-isopropyl-
CAS REGISTRY NUMBER :
479-92-5
BEILSTEIN REFERENCE NO. :
0204533
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C14-H18-N2-O
MOLECULAR WEIGHT :
230.34
WISWESSER LINE NOTATION :
T5NNVJ A1 BR& DY1&1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,601,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,401,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
295 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,434,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 61,205,1937
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
RTECS CD2800000
HS Code 2933110000

 Synthetic Route

~%

propyphenazone Structure

propyphenazone

CAS#:479-92-5

Literature: Yakugaku Zasshi, , vol. 57, p. 953,958; dtsch. Ref. S. 269 Chem.Abstr., , p. 2533 DE558473 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1186

 Customs

HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

More Articles
Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.

J. Pharm. Biomed. Anal. 43(2) , 515-21, (2007)

The combination of multicommutation and flow-through multioptosensing is presented in this work as a powerful strategy for the routine analysis of active principles in pharmaceuticals. By coupling met...

Green chromatography separation of analytes of greatly differing properties using a polyethylene glycol stationary phase and a low-toxic water-based mobile phase.

Anal. Bioanal. Chem 405(18) , 6105-15, (2013)

A simple, rapid, and environmentally friendly HPLC method was developed and validated for the separation of four compounds (4-aminophenol, caffeine, paracetamol, and propyphenazone) with different che...

VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.

J. Mass Spectrom. 45(7) , 734-9, (2010)

Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometr...

 Synonyms

ANTIBIOTICTPJ-B
causyth
2,3-Dimethyl-1-phenyl-4-isopropylpyrazolone
budirol
PROPYLPHENAZONE
MFCD00053368
arantil P
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-
Isopropylphenazone
Isopropyrine
Propyphenazon
Isopropylantipyrine
cibalgina
4-Isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone
1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one
isopropylantipyrin
EINECS 207-539-2
1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
propyphenazone
Isopyrine
Isopropylantipyrinum
Larodon
Eufibron
4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
4-Isopropylantipyrine
Isopropchin
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