4-Chloroguaiacol

Modify Date: 2025-08-26 17:52:40

4-Chloroguaiacol Structure
4-Chloroguaiacol structure
Common Name 4-Chloroguaiacol
CAS Number 16766-30-6 Molecular Weight 158.582
Density 1.3±0.1 g/cm3 Boiling Point 242.4±20.0 °C at 760 mmHg
Molecular Formula C7H7ClO2 Melting Point 16-17 °C(lit.)
MSDS Chinese USA Flash Point 100.4±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 4-Chloroguaiacol


4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MICs both of 110μg/mL[1].

 Names

Name 4-Chloro-2-Methoxyphenol
Synonym More Synonyms

 4-Chloroguaiacol Biological Activity

Description 4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MICs both of 110μg/mL[1].
Related Catalog
References

[1]. Patrícia Fontes Pinheiro,, et al. Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties. J Agric Food Chem. 2018 Jan 10;66(1):323-330.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 242.4±20.0 °C at 760 mmHg
Melting Point 16-17 °C(lit.)
Molecular Formula C7H7ClO2
Molecular Weight 158.582
Flash Point 100.4±21.8 °C
Exact Mass 158.013458
PSA 29.46000
LogP 2.36
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.554
InChIKey FVZQMMMRFNURSH-UHFFFAOYSA-N
SMILES COc1cc(Cl)ccc1O

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2909500000

 Synthetic Route

~89%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: Yadav; Reddy; Basak; Narsaiah Advanced Synthesis and Catalysis, 2004 , vol. 346, # 1 p. 77 - 82

~92%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: Sanz, Roberto; Martinez, Alberto; Marcos, Cesar; Fananas, Francisco J. Synlett, 2008 , # 13 p. 1957 - 1960

~43%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: Bovonsombat, Pakorn; Ali, Rameez; Khan, Chiraphorn; Leykajarakul, Juthamard; Pla-On, Kawin; Aphimanchindakul, Suraj; Pungcharoenpong, Natchapon; Timsuea, Nisit; Arunrat, Anchalee; Punpongjareorn, Napat Tetrahedron, 2010 , vol. 66, # 34 p. 6928 - 6935

~%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: EP1134220 A1, ;

~%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: Gazzetta Chimica Italiana, , vol. 63, p. 612,620

~%

4-Chloroguaiacol Structure

4-Chloroguaiacol

CAS#:16766-30-6

Literature: Journal of the Chemical Society, , p. 3681,3683

 Customs

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

4-Chloroguaiacol
Phenol, 4-chloro-2-methoxy-
MFCD00070774
2-Methoxy-4-chloro-phenol
4-Chloro-2-methoxyphenol
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