5-epi-Isofagomine

Modify Date: 2024-01-02 19:24:40

5-epi-Isofagomine Structure
5-epi-Isofagomine structure
Common Name 5-epi-Isofagomine
CAS Number 169105-89-9 Molecular Weight 147.17
Density 1.3±0.1 g/cm3 Boiling Point 317.2±37.0 °C at 760 mmHg
Molecular Formula C6H13NO3 Melting Point N/A
MSDS N/A Flash Point 171.8±17.1 °C

 Use of 5-epi-Isofagomine


Afegostat was previously in phase II clinical trials for the treatment of Gaucher's disease. The experiment was discontinued.

 Names

Name (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol
Synonym More Synonyms

 5-epi-Isofagomine Biological Activity

Description Afegostat was previously in phase II clinical trials for the treatment of Gaucher's disease. The experiment was discontinued.
Related Catalog
References

[1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 317.2±37.0 °C at 760 mmHg
Molecular Formula C6H13NO3
Molecular Weight 147.17
Flash Point 171.8±17.1 °C
PSA 72.72000
LogP -1.80
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.535

 Synthetic Route

 Synonyms

IFM
5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE
(3R,4R,5S)-5-(Hydroxymethyl)piperidine-3,4-diol
5-epi-Isofagomine
3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5S)-
iso-Fagomine
(3R,4R,5S)-5-(Hydroxymethyl)-3,4-piperidinediol
1oif
D-Isofagomine
Afegostat