BLU554
Modify Date: 2025-09-10 20:28:34
BLU554 structure
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Common Name | BLU554 | ||
|---|---|---|---|---|
| CAS Number | 1707289-21-1 | Molecular Weight | 503.378 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H24Cl2N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BLU554BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
| Name | BLU554 |
|---|---|
| Synonym | More Synonyms |
| Description | BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
|---|---|
| Related Catalog | |
| Target |
FGFR4 |
| In Vitro | Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H24Cl2N4O4 |
| Molecular Weight | 503.378 |
| Exact Mass | 502.117462 |
| LogP | 3.14 |
| Index of Refraction | 1.647 |
| InChIKey | MGZKYOAQVGSSGC-DLBZAZTESA-N |
| SMILES | C=CC(=O)NC1CCOCC1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1 |
| Storage condition | -20℃ |
| 2-Propenamide, N-[3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]- |
| N-(3-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}tetrahydro-2H-pyran-4-yl)acrylamide |
| BLU-554 |