DOTA-NHS-ester
Modify Date: 2024-01-03 10:54:38
DOTA-NHS-ester structure
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Common Name | DOTA-NHS-ester | ||
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| CAS Number | 170908-81-3 | Molecular Weight | 501.48800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H31N5O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DOTA-NHS-esterDOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. |
| Name | DOTA mono-N-hydroxysuccinimide ester |
|---|---|
| Synonym | More Synonyms |
| Description | DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. |
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| Related Catalog | |
| In Vitro | DOTA-NHS-ester can be used to modify human serum albumin (HSA) to produce DOTA-HSA. And DOTA-HSA is furtherly modified by Sulfo-SMCC (HY-D0975) to obtain DOTA-HSA-SMCC. DOTA-HSA-SMCC is conjugated to ZHER2:342 and the final product is DOTA-HSA-ZHER2:342[1]. In a cell uptake assay, DOTA-HSA-ZHER2:342 is labeled by 64Cu, 64Cu-DOTA-HSA-ZHER2:342 (0.5-2 hours) slowly accumulates in the SKOV3 cells and reaches 0.71% of the applied activity at 0.5 h and the uptake increased to 1.58% at 2 h[1]. |
| In Vivo | In a microPET images of a mouse bearing SKOV3 tumor, 64Cu-DOTA-HSA-ZHER2:342 is injected to the mouse tail. microPET images of a mouse bearing SKOV3 tumor at 1, 4, 24 and 48 h after tail vein injection. The SKOV3 tumor is visible with a low tumor-to-background contrast at 1 h post-injection (p.i.), but with a very good tumor-to-background contrast at 4 and 24 h p.i. Quantification analysis reveals that the SKOV3 tumor uptake values increases with time and are found to be 5.63%, 9.98%, 14.34% and 14.12% ID/g at 1, 4, 24, and 48 h, respectively[1]. |
| References |
| Molecular Formula | C20H31N5O10 |
|---|---|
| Molecular Weight | 501.48800 |
| Exact Mass | 501.20700 |
| PSA | 188.54000 |
| Hazard Codes | Xn |
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| HS Code | 2933990090 |
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~94%
DOTA-NHS-ester CAS#:170908-81-3 |
| Literature: Li, Cong; Winnard Jr., Paul T.; Takagi, Tomoyo; Artemov, Dmitri; Bhujwalla, Zaver M. Journal of the American Chemical Society, 2006 , vol. 128, # 47 p. 15072 - 15073 |
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid,10-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]- |
| 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid,1-(2,5-dioxo-1-pyrrolidinyl) ester |