Varespladib methyl

Modify Date: 2024-01-05 11:34:02

Varespladib methyl Structure
Varespladib methyl structure
 Common Name Varespladib methyl
CAS Number 172733-08-3 Molecular Weight 394.42000
Density N/A Boiling Point N/A
Molecular Formula C22H22N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Varespladib methyl


Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

 Names

Name (3-aminooxalyl-1-benzyl-2-ethyl-1h-indol-4-yloxy)-acetic acid methyl ester
Synonym More Synonyms

 Varespladib methyl Biological Activity

Description Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
Related Catalog
Target

phospholipase A2 (PLA2)[1]

In Vitro Varespladib methyl (LY333013) is an orally-administered methyl ester pro-drug that is metabolized to LY315920[1]. Varespladib and its orally bioavailable prodrug, Varespladib methyl (methyl-Varespladib) shows high-level secretory PLA2 (sPLA2) inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents[2].
References

[1]. Bradley JD, et al. A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol. 2005 Mar;32(3):417-23.

[2]. Lewin M, et al. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 Aug 25;8(9). pii: E248.

 Chemical & Physical Properties

Molecular Formula C22H22N2O5
Molecular Weight 394.42000
Exact Mass 394.15300
PSA 100.62000
LogP 3.17210

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

Varespladib methyl
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Chemsrc provides Varespladib methyl(CAS#:172733-08-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Varespladib methyl are included as well.>> amp version: Varespladib methyl

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