Varespladib methyl

Modify Date: 2025-08-23 20:59:24

Varespladib methyl structure	Common Name	Varespladib methyl
	CAS Number	172733-08-3	Molecular Weight	394.42000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₂N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Varespladib methyl

Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

Name	(3-aminooxalyl-1-benzyl-2-ethyl-1h-indol-4-yloxy)-acetic acid methyl ester
Synonym	More Synonyms

Description	Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	phospholipase A2 (PLA2)[1]
In Vitro	Varespladib methyl (LY333013) is an orally-administered methyl ester pro-drug that is metabolized to LY315920[1]. Varespladib and its orally bioavailable prodrug, Varespladib methyl (methyl-Varespladib) shows high-level secretory PLA2 (sPLA2) inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents[2].
References	[1]. Bradley JD, et al. A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol. 2005 Mar;32(3):417-23. [2]. Lewin M, et al. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 Aug 25;8(9). pii: E248.

Molecular Formula	C₂₂H₂₂N₂O₅
Molecular Weight	394.42000
Exact Mass	394.15300
PSA	100.62000
LogP	3.17210

Precursor 0
DownStream 1
CAS#:172733-42-5 Varespladib sodium

Varespladib methyl

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