TEI-9648

Modify Date: 2024-01-21 13:13:55

TEI-9648 structure	Common Name	TEI-9648
	CAS Number	173388-21-1	Molecular Weight	426.58800
	Density	N/A	Boiling Point	618.492ºC at 760 mmHg
	Molecular Formula	C₂₇H₃₈O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	204.543ºC

Use of TEI-9648

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2].

Name	(1S,3R,5Z,7E,23R)-1,3-Dihydroxy-23,26-epoxy-9,10-secocholesta-5,7 ,10,25(27)-tetraen-26-one

Description	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2].
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has consistently weaker suppressive effect than TEI-9647[1]. TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1]. TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1 nM) in HL-60 cells[1].
References	[1]. Miura D, et al. Antagonistic action of novel 1α,25-dihydroxyvitamin D₃-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1α,25-dihydroxyvitamin D₃. J Biol Chem. 1999 Jun 4;274(23):16392-9. [2]. Kazuya Takenouchi, et al. Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D₃ antagonists. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):31-4.

Boiling Point	618.492ºC at 760 mmHg
Molecular Formula	C₂₇H₃₈O₄
Molecular Weight	426.58800
Flash Point	204.543ºC
Exact Mass	426.27700
PSA	66.76000
LogP	5.02530
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.567

DC Chemicals Limited
China
Product Name: TEI-9648
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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TEI-9648

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