TEI-9648
Modify Date: 2024-01-21 13:13:55
TEI-9648 structure
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Common Name | TEI-9648 | ||
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| CAS Number | 173388-21-1 | Molecular Weight | 426.58800 | |
| Density | N/A | Boiling Point | 618.492ºC at 760 mmHg | |
| Molecular Formula | C27H38O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 204.543ºC | |
Use of TEI-9648TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. |
| Name | (1S,3R,5Z,7E,23R)-1,3-Dihydroxy-23,26-epoxy-9,10-secocholesta-5,7 ,10,25(27)-tetraen-26-one |
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| Description | TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. |
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| Related Catalog | |
| In Vitro | TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has consistently weaker suppressive effect than TEI-9647[1]. TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1]. TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1 nM) in HL-60 cells[1]. |
| References |
| Boiling Point | 618.492ºC at 760 mmHg |
|---|---|
| Molecular Formula | C27H38O4 |
| Molecular Weight | 426.58800 |
| Flash Point | 204.543ºC |
| Exact Mass | 426.27700 |
| PSA | 66.76000 |
| LogP | 5.02530 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.567 |