4-AMINO-1,8-NAPHTHALIMIDE

Modify Date: 2024-01-04 10:01:39

4-AMINO-1,8-NAPHTHALIMIDE structure	Common Name	4-AMINO-1,8-NAPHTHALIMIDE
	CAS Number	1742-95-6	Molecular Weight	212.20
	Density	1.105 g/mL at 25ºC(lit.)	Boiling Point	544.1ºC at 760 mmHg
	Molecular Formula	C₁₂H₈N₂O₂	Melting Point	360ºC
	MSDS	Chinese USA	Flash Point	282.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of 4-AMINO-1,8-NAPHTHALIMIDE

4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].

Name	4-amino-1,8-naphthalimide
Synonym	More Synonyms

Description	4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100.

Density	1.105 g/mL at 25ºC(lit.)
Boiling Point	544.1ºC at 760 mmHg
Melting Point	360ºC
Molecular Formula	C₁₂H₈N₂O₂
Molecular Weight	212.20
Flash Point	282.8ºC
Exact Mass	212.05900
PSA	75.95000
LogP	1.64270
Vapour Pressure	6.75E-12mmHg at 25°C
Index of Refraction	1.764

4-AMINO-1,8-NAPHTHALIMIDE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4081000

CHEMICAL NAME :: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 6-amino-

CAS REGISTRY NUMBER :: 1742-95-6

BEILSTEIN REFERENCE NO. :: 0177185

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H8-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(1),111,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	DE4081000

6-Nitro-1H,3H-b...

CAS#:6642-29-1

~51%

4-AMINO-1,8-NAP...

CAS#:1742-95-6

Literature: Alexiou, Michael; Tyman, John; Wilson, Ian Tetrahedron Letters, 1981 , vol. 22, # 24 p. 2303 - 2306

N/A

CAS#:26848-63-5

4-AMINO-1,8-NAP...

CAS#:1742-95-6

Literature: DE602944 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 370 US2006017 , ;

Precursor 1
CAS#:6642-29-1 6-Nitro-1H,3H-b...
DownStream 0

A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90 , 85-92, (2012)

A novel N-allyl-4-amino-substituted 1,8-naphthalimide dye, containing thiourea functional group with intense yellow-green fluorescence was successfully synthesized. Copolymerization was done with styr...

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

DNA Repair (Amst.) 12(9) , 774-85, (2013)

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key B...

[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin].

Wei Sheng Yan Jiu 41(2) , 173-9, (2012)

To explore the effect of inhibition of poly (ADP-ribose) polymerase-1 (PARP-1) on the sensitivity of cells to adriamycin (ADM).Mouse embryonic fibroblasts (MEFs) were divided into two groups according...

6-aminobenzo[de]isoquinoline-1,3-dione

EINECS 217-092-5

4-Amino-1,8-naphthalimide

6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione

MFCD00001892

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-AMINO-1,8-NAPHTHALIMIDE
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 4-Aminonaphthalimide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-aminonaphthalene-1,8-dicarboximide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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