1742-95-6

1742-95-6 structure

Name: 4-AMINO-1,8-NAPHTHALIMIDE
Chemical Name: 4-amino-1,8-naphthalimide
CAS Number: 1742-95-6
Molecular Formula: C₁₂H₈N₂O₂
Molecular Weight: 212.20
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2018-05-11 08:00:00
Modify Date: 2025-08-20 22:08:24
4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].

Name	4-amino-1,8-naphthalimide
Synonyms	6-aminobenzo[de]isoquinoline-1,3-dione EINECS 217-092-5 4-Amino-1,8-naphthalimide 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione MFCD00001892

Description	4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(1),111,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	DE4081000

6642-29-1

~51%

1742-95-6

Literature: Alexiou, Michael; Tyman, John; Wilson, Ian Tetrahedron Letters, 1981 , vol. 22, # 24 p. 2303 - 2306

26848-63-5

1742-95-6

Literature: DE602944 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 370 US2006017 , ;

Precursor 1
6642-29-1
DownStream 0