22-alpha-Hydroxy Cholesterol
22-alpha-Hydroxy Cholesterol structure
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Common Name | 22-alpha-Hydroxy Cholesterol | ||
|---|---|---|---|---|
| CAS Number | 17954-98-2 | Molecular Weight | 402.65 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 213.5±17.2 °C | |
Use of 22-alpha-Hydroxy Cholesterol22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (22R)-22-hydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.65 |
| Flash Point | 213.5±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.66 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | RZPAXNJLEKLXNO-GFKLAVDKSA-N |
| SMILES | CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 2 | |
CAS#:19243-30-2
CAS#:481-21-0This table lists relevant public references with title, journal and publication metadata for this compound.
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Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxys... |
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HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.
Toxicol. Appl. Pharmacol. 282(1) , 20-9, (2015) Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD distu... |
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Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.
Biol. Reprod. 86(1) , 1-12, (2012) In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Narthesterol |
| 22BF-HYDROXYCHOLESTEROL |
| 22(S)-hydroxycholesterol |
| (3β,22S)-Cholest-5-ene-3,22-diol |
| 22BETA-HYDROXYCHOLESTEROL |
| 22R-OHC |
| 22(R)-HYDROXYCHOLESTEROL |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of (22R)-22-hydroxycholesterol? |
| A: Related downstream products(CAS) of (22R)-22-hydroxycholesterol: 19243-30-2;481-21-0. |
| Q: What is the InChIKey of (22R)-22-hydroxycholesterol? |
| A: InChIKey of (22R)-22-hydroxycholesterol is RZPAXNJLEKLXNO-GFKLAVDKSA-N. |
| Q: What English synonyms does (22R)-22-hydroxycholesterol have? |
| A: English synonyms of (22R)-22-hydroxycholesterol: Narthesterol, 22BF-HYDROXYCHOLESTEROL, 22(S)-hydroxycholesterol, (3β,22S)-Cholest-5-ene-3,22-diol, 22BETA-HYDROXYCHOLESTEROL, 22R-OHC, 22(R)-HYDROXYCHOLESTEROL. |
| Q: What is the boiling point of (22R)-22-hydroxycholesterol? |
| A: Boiling point of (22R)-22-hydroxycholesterol is 513.1±23.0 °C at 760 mmHg. |
| Q: What are the uses of (22R)-22-hydroxycholesterol? |
| A: Main uses of (22R)-22-hydroxycholesterol: 22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1]. |
| Q: What is the molecular formula of (22R)-22-hydroxycholesterol? |
| A: Molecular formula of (22R)-22-hydroxycholesterol is C27H46O2. |
| Q: What is the polar surface area (PSA) of (22R)-22-hydroxycholesterol? |
| A: Polar surface area (PSA) of (22R)-22-hydroxycholesterol is 40.46000. |
| Q: What is the SMILES notation of (22R)-22-hydroxycholesterol? |
| A: SMILES notation of (22R)-22-hydroxycholesterol is CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C. |
| Q: What is the English name of (22R)-22-hydroxycholesterol? |
| A: The English name of (22R)-22-hydroxycholesterol is (22R)-22-hydroxycholesterol. |
| Q: What is the LogP of (22R)-22-hydroxycholesterol? |
| A: LogP of (22R)-22-hydroxycholesterol is 7.66. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |