22-alpha-Hydroxy Cholesterol

Modify Date: 2025-08-25 11:45:56

22-alpha-Hydroxy Cholesterol structure	Common Name	22-alpha-Hydroxy Cholesterol
	CAS Number	17954-98-2	Molecular Weight	402.65
	Density	1.0±0.1 g/cm3	Boiling Point	513.1±23.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₆O₂	Melting Point	N/A
	MSDS	USA	Flash Point	213.5±17.2 °C

Use of 22-alpha-Hydroxy Cholesterol

22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1].

Name	(22R)-22-hydroxycholesterol
Synonym	More Synonyms

Description	22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease
References	[1]. Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275(36):28240-5.

Density	1.0±0.1 g/cm3
Boiling Point	513.1±23.0 °C at 760 mmHg
Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.65
Flash Point	213.5±17.2 °C
Exact Mass	402.349792
PSA	40.46000
LogP	7.66
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.536
InChIKey	RZPAXNJLEKLXNO-GFKLAVDKSA-N
SMILES	CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Precursor 0
DownStream 2
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Name: Agonist activity at LXR in human HepG2 cells assessed as reduction in SREBP1c proteol...
Source: ChEMBL
Target: Oxysterols receptor LXR-beta
External Id: CHEMBL5372115

Name: Maximal induction of liver X receptor-alpha receptor in transactivation assay
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL836029

Name: Agonist activity at RXRalpha in mouse peritoneal macrophages assessed as ApoAI-mediat...
Source: ChEMBL
Target: Retinoic acid receptor RXR-alpha
External Id: CHEMBL1219324

Name: Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luc...
Source: ChEMBL
Target: Oxysterols receptor LXR-beta
External Id: CHEMBL4040642

Name: Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by lu...
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL4040641

Name: Effective concentration against liver X receptor-alpha in HEK293 cell transactivation...
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL832531

Name: Effective concentration against liver X receptor-beta in HEK293 transactivation assay...
Source: ChEMBL
Target: Oxysterols receptor LXR-beta
External Id: CHEMBL832871

Name: Agonist activity at full length human LXRbeta transfected in HEK293T cells co-express...
Source: ChEMBL
Target: Oxysterols receptor LXR-beta
External Id: CHEMBL5372100

Name: Agonist activity at full length human LXRalpha transfected in HEK293T cells co-expres...
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL5372099

Name: Percent inhibition of [3H2]-F3-methyl AA (1) binding to liver X receptor-beta at 100 ...
Source: ChEMBL
Target: Oxysterols receptor LXR-beta
External Id: CHEMBL835560

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