Acid-PEG6-mono-methyl ester

Modify Date: 2024-01-02 11:16:39

Acid-PEG6-mono-methyl ester Structure
Acid-PEG6-mono-methyl ester structure
Common Name Acid-PEG6-mono-methyl ester
CAS Number 1807512-38-4 Molecular Weight 396.430
Density 1.1±0.1 g/cm3 Boiling Point 503.7±50.0 °C at 760 mmHg
Molecular Formula C17H32O10 Melting Point N/A
MSDS N/A Flash Point 168.4±23.6 °C

 Use of Acid-PEG6-mono-methyl ester


Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Acid-PEG6-mono-methyl ester
Synonym More Synonyms

 Acid-PEG6-mono-methyl ester Biological Activity

Description Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 503.7±50.0 °C at 760 mmHg
Molecular Formula C17H32O10
Molecular Weight 396.430
Flash Point 168.4±23.6 °C
Exact Mass 396.199554
LogP -1.80
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.460

 Synonyms

MFCD28976695
4,7,10,13,16,19-Hexaoxadocosane-1,22-dioic acid, monomethyl ester
3-Oxo-2,6,9,12,15,18,21-heptaoxatetracosan-24-oic acid