IACS-10759 Hydrochloride structure
|
Common Name | IACS-10759 Hydrochloride | ||
---|---|---|---|---|
CAS Number | 1807523-99-4 | Molecular Weight | 599.02 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H26ClF3N6O4S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of IACS-10759 HydrochlorideIACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
Name | IACS-10759 Hydrochloride |
---|
Description | IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
---|---|
Related Catalog | |
Target |
OXPHOS[1] |
In Vitro | IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1]. |
In Vivo | IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1]. |
References |
Molecular Formula | C25H26ClF3N6O4S |
---|---|
Molecular Weight | 599.02 |
Storage condition | 2-8℃ |