IACS-10759 Hydrochloride

Modify Date: 2024-01-03 20:59:52

IACS-10759 Hydrochloride Structure
IACS-10759 Hydrochloride structure
Common Name IACS-10759 Hydrochloride
CAS Number 1807523-99-4 Molecular Weight 599.02
Density N/A Boiling Point N/A
Molecular Formula C25H26ClF3N6O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IACS-10759 Hydrochloride


IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

 Names

Name IACS-10759 Hydrochloride

 IACS-10759 Hydrochloride Biological Activity

Description IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).
Related Catalog
Target

OXPHOS[1]

In Vitro IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1].
In Vivo IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1].
References

[1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380

 Chemical & Physical Properties

Molecular Formula C25H26ClF3N6O4S
Molecular Weight 599.02
Storage condition 2-8℃
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Price: ¥2899/10 mM * 1 mL in DMSO

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