IACS-10759 Hydrochloride
Modify Date: 2024-01-03 20:59:52
IACS-10759 Hydrochloride structure
|
Common Name | IACS-10759 Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1807523-99-4 | Molecular Weight | 599.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26ClF3N6O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IACS-10759 HydrochlorideIACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
| Name | IACS-10759 Hydrochloride |
|---|
| Description | IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). |
|---|---|
| Related Catalog | |
| Target |
OXPHOS[1] |
| In Vitro | IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1]. |
| In Vivo | IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1]. |
| References |
| Molecular Formula | C25H26ClF3N6O4S |
|---|---|
| Molecular Weight | 599.02 |
| Storage condition | 2-8℃ |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: IACS-10759 Hydrochloride
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: IACS-10759 Hydrochloride
- Price: $950.0/100mg $1900.0/250mg $3800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: IACS-10759 Hydrochloride
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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IACS-10759 Hydrochloride suppliers
Price: ￥2899/10 mM * 1 mL in DMSO
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