SMS1-IN-1

Modify Date: 2024-01-14 17:46:00

SMS1-IN-1 Structure
SMS1-IN-1 structure
Common Name SMS1-IN-1
CAS Number 1807943-38-9 Molecular Weight 503.41
Density N/A Boiling Point N/A
Molecular Formula C23H23BrN2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SMS1-IN-1


SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].

 Names

Name SMS1-IN-1

 SMS1-IN-1 Biological Activity

Description SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1].
Related Catalog
Target

IC50: 2.1 μM (SMS1)[1]

In Vitro SMS1-IN-1 (2.5, 10 and 50 μM) has a dose-dependent inhibitory effect against SMS1, and is against SMS1 with an IC50 value of 2.1 μM[1].
References

[1]. Li YL, et al. Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.Bioorg Med Chem. 2015 Sep 15;23(18):6173-84.

 Chemical & Physical Properties

Molecular Formula C23H23BrN2O4S
Molecular Weight 503.41
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