CXCR2-IN-68
Modify Date: 2025-12-01 19:02:27
CXCR2-IN-68 structure
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Common Name | CXCR2-IN-68 | ||
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| CAS Number | 1838123-21-9 | Molecular Weight | 414.901 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H23ClN2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CXCR2-IN-68CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID). |
| Name | CXCR2-IN-68 |
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| Description | CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID). |
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| References | References 1. Lu H, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01854. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C18H23ClN2O5S |
|---|---|
| Molecular Weight | 414.901 |
| InChIKey | DNXKACKCTLURQN-ACJLOTCBSA-N |
| SMILES | CC1=CCCC1NC(=O)Nc1ccc(Cl)c(S(=O)(=O)C2(C)CCOC2)c1O |