Heat Shock Protein Inhibitor II

Modify Date: 2025-08-25 17:23:49

Heat Shock Protein Inhibitor II structure	Common Name	Heat Shock Protein Inhibitor II
	CAS Number	1859-42-3	Molecular Weight	217.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Heat Shock Protein Inhibitor II

KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].

Name	3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
Synonym	More Synonyms

Description	KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9. [2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

References

[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9.

[2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.

Molecular Formula	C₁₂H₁₁NO₃
Molecular Weight	217.22
Exact Mass	217.07400
PSA	47.56000
LogP	1.64740

2-oxo-3-piperonyliden-pyrrolidin

HEAT SHOCK PROTEIN INHIBITOR II

3,4-methylenedioxy-benzylidine-γ-butyrolactam

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Heat Shock Protein Inhibitor II

Use of Heat Shock Protein Inhibitor II

Names

Heat Shock Protein Inhibitor II Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.