热激蛋白抑制剂II

• 常用名: 热激蛋白抑制剂II
• 英文名: Heat Shock Protein Inhibitor II
• CAS号: 1859-42-3
• 分子量: 217.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₁NO₃
• 熔点: N/A
• 闪点: N/A

热激蛋白抑制剂II用途

KNK423 是一种特异性热休克蛋白 (HSP) 合成抑制剂。KNK423 可通过阻断 HSP70 来提高 Amphotericin B 抑制抗性 Aspergillus terreus 的效率。KNK423 可用于癌症和细菌感染的研究。

热激蛋白抑制剂II名称

• 中文名: 热激蛋白抑制剂II
• 英文名: 3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one

热激蛋白抑制剂II生物活性

• 描述: KNK423 是一种特异性热休克蛋白 (HSP) 合成抑制剂。KNK423 可通过阻断 HSP70 来提高 Amphotericin B 抑制抗性 Aspergillus terreus 的效率。KNK423 可用于癌症和细菌感染的研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 参考文献:

  [1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9.

  [2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.

热激蛋白抑制剂II物理化学性质

• 分子式: C₁₂H₁₁NO₃
• 分子量: 217.22
• 精确质量: 217.07400
• PSA: 47.56000
• LogP: 1.64740
• InChIKey: IJPPHWXYOJXQMV-WEVVVXLNSA-N
• SMILES: O=C1NCCC1=Cc1ccc2c(c1)OCO2
• 储存条件: -20°C，密闭，干燥

热激蛋白抑制剂II靶点实验

查看更多实验

实验名称：Neurotoxicity in Kunming mouse assessed as motor impairment by measuring reduction in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222576

实验名称：Anticonvulsant activity in ip dosed Kunming mouse assessed as protection against maxi... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222578

实验名称：Anticonvulsant activity in ip dosed Kunming mouse assessed as minimum dose required t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222577

实验名称：Anticonvulsant activity in Kunming mouse assessed as protection against subcutaneousl... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222572

实验名称：Anticonvulsant activity in Kunming mouse assessed as protection against subcutaneousl... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222574

实验名称：Neurotoxicity in Kunming mouse assessed as motor impairment by measuring reduction in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222568

实验名称：Anticonvulsant activity in ip dosed Kunming mouse assessed as minimum dose required t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222570

实验名称：Anticonvulsant activity in ip dosed Kunming mouse assessed as minimum dose required t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222569

实验名称：Protection index, ratio of TD50 for neurotoxicity by motor impairment in Kunming mous... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222580

实验名称：Neurotoxicity in ip dosed Kunming mouse assessed as motor impairment by measuring red... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4222579

共10条，当前第1页，共1页

1

热激蛋白抑制剂II英文别名

• 2-oxo-3-piperonyliden-pyrrolidin
• HEAT SHOCK PROTEIN INHIBITOR II
• 3,4-methylenedioxy-benzylidine-γ-butyrolactam