Actein

Modify Date: 2024-01-09 12:34:11

Actein structure	Common Name	Actein
	CAS Number	18642-44-9	Molecular Weight	676.834
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₇H₅₆O₁₁	Melting Point	246-250ºC
	MSDS	N/A	Flash Point	N/A

Use of Actein

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].

Name	Actein
Synonym	More Synonyms

Description	Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> MAPK/ERK Pathway >> JNK
References	[1]. Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183. [2]. Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

Signaling Pathways >> MAPK/ERK Pathway >> JNK

References

[1]. Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183.

[2]. Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.

Density	1.4±0.1 g/cm3
Melting Point	246-250ºC
Molecular Formula	C₃₇H₅₆O₁₁
Molecular Weight	676.834
Exact Mass	676.382263
PSA	156.67000
LogP	5.67
Index of Refraction	1.610

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa.

J. Nat. Prod. 73(12) , 2024-8, (2010)

Black cohosh (Actaea racemosa) is a frequently used herbal remedy for the treatment of mild climacteric symptoms. In the present study, the modulation of γ-aminobutryic acid (GABA)-induced chloride cu...

Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells.

Phytomedicine 15(6-7) , 504-11, (2008)

The purpose of this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the natur...

Studies on the Chinese crude drug "shoma." IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome.

Chem. Pharm. Bull. 43(5) , 771-6, (1995)

Three new cyclolanostanol xylosides were isolated from a batch of commercial Cimicifuga Rhizome, cimicifugoside H-1 (1), C35H52O9, mp 260-262 degrees C, [alpha]D -43.5 degrees, cimicifugoside H-2 (2),...

β-D-Xylopyranoside, (1'R,2S,4'S,4aR,5'S,5aR,7R,7aR,7bR,8R,10R,11aS,12aS,12bS,14aR)-7-(acetyloxy)hexadecahydro-4'-hydroxy-1,1,5',7a,8,12a-hexamethylspiro[5H-cyclopropa[1',8'a]naphth[2',1':4,5]indeno [2,1-b]pyran-10(2H),2'-[3,6]dioxabicyclo[3.1.0]hexan]-2-yl

(1'R,2S,4'S,4aR,5'S,5aR,7R,7aR,7bR,8R,10R,11aS,12aS,12bS,14aR)-4'-Hydroxy-1,1,5',7a,8,12a-hexamethyl-2-(β-D-xylopyranosyloxy)hexadecahydro-2H-spiro[cyclopropa[1',8a']naphtho[2',1':4,5]indeno[2,1-b] pyran-10,2'-[3,6]dioxabicyclo[3.1.0]hexan]-7-yl acetate

BioBioPha
China
Product Name: Actein
Price: ￥3900.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng