RA-2

Modify Date: 2024-01-16 15:48:33

RA-2 Structure
RA-2 structure
Common Name RA-2
CAS Number 1867107-62-7 Molecular Weight 414.356
Density 1.4±0.1 g/cm3 Boiling Point 590.5±50.0 °C at 760 mmHg
Molecular Formula C22H16F2O6 Melting Point N/A
MSDS N/A Flash Point 310.9±30.1 °C

 Use of RA-2


RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].

 Names

Name RA-2
Synonym More Synonyms

 RA-2 Biological Activity

Description RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].
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References

[1]. Oliván-Viguera A, et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015;87(2):338-348.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 590.5±50.0 °C at 760 mmHg
Molecular Formula C22H16F2O6
Molecular Weight 414.356
Flash Point 310.9±30.1 °C
Exact Mass 414.091492
LogP 5.91
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.620

 Synonyms

1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate
RA-2
1,3-Phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate)
Benzoic acid, 3-fluoro-4-hydroxy-, 1,3-phenylenebis(methylene) ester
1,1'-[1,3-Phenylenebis(methylene)]-3-fluoro-4-hydroxy-benzoic acid ester
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