MaxiPost
Modify Date: 2026-07-14 23:16:18
MaxiPost structure
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Common Name | MaxiPost | ||
|---|---|---|---|---|
| CAS Number | 187523-35-9 | Molecular Weight | 359.70300 | |
| Density | 1.5g/cm3 | Boiling Point | 436.9ºC at 760mmHg | |
| Molecular Formula | C16H10ClF4NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 218ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of MaxiPostFlindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo[1][2]. |
| Name | (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo[1][2]. |
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| Related Catalog | |
| Target |
Ki: 3.7 μM (Kv7.1), 230 μM (Kv7.4), 605 μM (Kv7.5)[1] |
| In Vitro | Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with Kis of 230 and 605 μM, respectively[1]. Flindokalner (1-10 μM) causes inhibition of the Ca2+ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes[2]. |
| In Vivo | Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect[1]. In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile[1]. Animal Model: Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)[1] Dosage: i.p. Administration: 3, 10, 30 mg/kg Result: Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze. |
| References |
| Density | 1.5g/cm3 |
|---|---|
| Boiling Point | 436.9ºC at 760mmHg |
| Molecular Formula | C16H10ClF4NO2 |
| Molecular Weight | 359.70300 |
| Flash Point | 218ºC |
| Exact Mass | 359.03400 |
| PSA | 38.33000 |
| LogP | 4.67060 |
| Vapour Pressure | 7.82E-08mmHg at 25°C |
| Index of Refraction | 1.574 |
| InChIKey | ULYONBAOIMCNEH-HNNXBMFYSA-N |
| SMILES | COc1ccc(Cl)cc1C1(F)C(=O)Nc2cc(C(F)(F)F)ccc21 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313 |
| RIDADR | NONH for all modes of transport |
| RTECS | NM3249000 |
![Ethyl 2-[2-(Boc-amino)-4-(trifluoromethyl)phenyl]-2-oxoacetate structure](https://image.chemsrc.com/caspic/305/159684-36-3.png)
![5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid methyl ester structure](https://image.chemsrc.com/caspic/025/206194-00-5.png)
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Name: Tested for the effect on whole cell maxi-K current in HEK 293 cells at 10 nM
Source: ChEMBL
Target: HEK293
External Id: CHEMBL689201
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Name: Tested for the effect on whole cell maxi-K current in HEK 293 cells at 100 nM
Source: ChEMBL
Target: HEK293
External Id: CHEMBL689203
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Name: Tested for the effect on whole cell maxi-K current in HEK 293 cells at 1000 nM
Source: ChEMBL
Target: HEK293
External Id: CHEMBL689204
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Name: Human Kv7.5 (Voltage-gated potassium channels)
Source: IUPHAR-DB
Target: Kv7.5 (Voltage-gated potassium channels) [Homo sapiens]
External Id: 564_Human
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Name: Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles...
Source: ChEMBL
Target: Bile salt export pump
External Id: CHEMBL4011663
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Name: Human Kv7.2 (Voltage-gated potassium channels)
Source: IUPHAR-DB
Target: Kv7.2 (Voltage-gated potassium channels) [Homo sapiens]
External Id: 561_Human
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Name: Human Kv7.4 (Voltage-gated potassium channels)
Source: IUPHAR-DB
Target: Kv7.4 (Voltage-gated potassium channels) [Homo sapiens]
External Id: 563_Human
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Name: Evaluated for Volume of distribution after iv administration of 5 mg/kg to male Sprag...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL620196
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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| [14C]-Flindokalner |
| MaxiPost |
| (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one |
| (3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one |
| (S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-trifluoromethyl-1,3-dihydroindol-2-one |
| Flindokalner |
| Flindokalner [USAN:INN] |
| Maxipost (TN) |