PNU 109291

Modify Date: 2024-01-03 21:49:58

PNU 109291 Structure
PNU 109291 structure
Common Name PNU 109291
CAS Number 187665-60-7 Molecular Weight 409.52
Density N/A Boiling Point N/A
Molecular Formula C24H31N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PNU 109291


PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].

 Names

Name (1R)-1-[2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide
Synonym More Synonyms

 PNU 109291 Biological Activity

Description PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
Related Catalog
In Vivo PNU109291 (0.24、2.4、7.3、24.4、73.3 nmol/kg;皮下注射) 减少猪的三叉神经节刺激引起的硬脑膜血浆外渗[1]。 PNU109291 (3 µM) 抑制大鼠弗氏佐剂 (CFA) 诱发的 EPSC(兴奋性突触后电流),但不抑制注射盐水的处理组[2]。 Animal Model: 200-500g, male Hartley guinea pigs[1] Dosage: 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg Administration: S.c.; 60 min before electrical stimulation Result: Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg.
References

[1]. Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38(7):1043-53.  

[2]. Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177(16):3730-3743.  

 Chemical & Physical Properties

Molecular Formula C24H31N3O3
Molecular Weight 409.52
Exact Mass 409.23700
PSA 54.04000
LogP 3.27470

 Synonyms

DMNPE-caged ATP diammonium salt
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