SF-3-030
Modify Date: 2024-04-06 17:31:58
SF-3-030 structure
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Common Name | SF-3-030 | ||
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| CAS Number | 1883721-73-0 | Molecular Weight | 324.365 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H12O5S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SF-3-030SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation. |
| Name | SF-3-030 |
|---|
| Description | SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation. |
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| References | 1. Ramon Martinez 3rd, et al. J Pharmacol Exp Ther. 2021 Jan;376(1):84-97. |
| Molecular Formula | C14H12O5S2 |
|---|---|
| Molecular Weight | 324.365 |