1883721-73-0
1883721-73-0 structure
- Name: SF-3-030
- Chemical Name: SF-3-030
- CAS Number: 1883721-73-0
- Molecular Formula: C14H12O5S2
- Molecular Weight: 324.365
- Create Date: 2022-06-27 18:30:32
- Modify Date: 2024-04-06 17:31:58
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SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation.
| Name | SF-3-030 |
|---|
| Description | SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation. |
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| References | 1. Ramon Martinez 3rd, et al. J Pharmacol Exp Ther. 2021 Jan;376(1):84-97. |
| Molecular Formula | C14H12O5S2 |
|---|---|
| Molecular Weight | 324.365 |