dBET57

Modify Date: 2024-04-09 14:37:15

dBET57 Structure
dBET57 structure
Common Name dBET57
CAS Number 1883863-52-2 Molecular Weight 699.18
Density N/A Boiling Point N/A
Molecular Formula C34H31ClN8O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of dBET57


dBET57 is a potent and selective heterobifunctional degrader of BRD4 based on the PROTAC technology, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1].

 Names

Name dBET57

 dBET57 Biological Activity

Description dBET57 is a potent and selective heterobifunctional degrader of BRD4 based on the PROTAC technology, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1].
Related Catalog
Target

DC50/5h: 500 nM (BRD4BD1)[1]

References

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.

 Chemical & Physical Properties

Molecular Formula C34H31ClN8O5S
Molecular Weight 699.18
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